Immunological pathomechanisms in vitiligo
Vitiligo is a depigmenting disorder characterised by the loss of melanocytes from the cutaneous epidermis. Although the exact aetiology of vitiligo has not yet been established, the abnormal immune responses frequently observed in vitiligo patients have led to the suggestion that, in some cases, the condition has an autoimmune component. Briefly, circulating autoantibodies and autoreactive T cells that recognise pigment cell antigens have been detected in the sera of a significant proportion of vitiligo patients compared with healthy individuals. In addition, vitiligo is often associated with other disorders that have an autoimmune origin, including Hashimoto's thyroiditis, Graves' disease, type 1 insulin-dependent diabetes mellitus and Addison's disease. Furthermore, effective use of immunosuppressive therapies to treat vitiligo, the association of vitiligo with certain major histocompatibility complex antigens, and evidence from animal models of the disease have all added credence to the hypothesis that immune reactions play a role in vitiligo pathogenesis. This review presents and discusses the evidence for immunological pathomechanisms in vitiligo.
Key Words: Autoantibody; autoantigen; autoimmune; depigmentation; hypopigmentation; melanocyte; pigment cell; T lymphocyte; vitiligo.
c1 Division of Clinical Sciences, Northern General Hospital, University of Sheffield, Sheffield, S5 7AU, UK. Tel: +44 (0)114 271 4910; Fax: +44 (0)114 256 0458; E-mail: [email protected]