Cardiology in the Young

Brief Reports

Holt-Oram syndrome and multiple ventricular septal defects: an association suggesting a possible genetic marker?

Rolf G. Bennhagena1 and Samuel Menahema1 c1

a1 Department of Cardiology, Royal Children's Hospital, Melbourne, Australia


A family is described where the father has the many skeletal, but none of the cardiac abnormalities associated with the Holt-Oram syndrome. His two daughters have similar skeletal anomalies, but with identical cardiac lesions, as does another patient, raising the possibility of an associated genetic marker.

(Accepted December 11 1996)


c1 Professor S Menahem, Department of Cardiology, Royal Children's Hospital. Flemington Road, Parkville, Victoria. 3052, Australia. Tel: 61-3-9345 5715 Fax: 61-3-9345 6001.