Journal of the International Neuropsychological Society



The neuropsychological profiles of mild Alzheimer's disease and questionable dementia as compared to age-related cognitive decline


ELISE CACCAPPOLO-VAN  VLIET  a1, JENNIFER  MANLY  a1 a2, MING-XIN  TANG  a1 a4 a5, KAREN  MARDER  a1 a2 a4, KAREN  BELL  a1 a2 a4 and YAAKOV  STERN  a1 a2 a3 a4 c1
a1 Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, New York
a2 Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York
a3 Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York
a4 Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, New York
a5 Division of Biostatistics, Columbia University College of Physicians and Surgeons, New York, New York

Abstract

Test scores from a comprehensive neuropsychological battery administered to 1602 subjects consisting of 1347 subjects with probable Alzheimer's disease (AD), 100 subjects with questionable dementia (QD) and 155 non-demented elderly control subjects were cross-sectionally analyzed. Subjects with probable AD were categorized as mild (n = 244), moderate (n = 480), severe (n = 376), and very severe (n = 247) according to modified mini mental status exam (mMMSE) scores. Mean scores on individual neuropsychological tests are provided for each group of subjects. Stratified random sampling was performed to select a sample of mild AD subjects who were matched in age and education to non-demented elderly controls, and analyses focused on the performance of QD subjects and mild AD subjects, whose scores were compared to those of the elderly control subjects. Selected scores were organized by cognitive domain and logistic regressions were used to determine the domains and individual tests within each that were most predictive of group status. Results suggested a profile of scores associated with QD and mild AD including impaired recall of verbal information for both groups. Areas of lower functioning in QD subjects as compared to elderly controls included category fluency and visuospatial ability. (JINS, 2003, 9, 720–732.)

(Received September 25 2001)
(Revised August 2 2002)
(Accepted August 5 2002)


Key Words: Alzheimer's disease; Questionable dementia; Age-related cognitive decline; Neuropsychological testing.

Correspondence:
c1 Reprint requests to: Yaakov Stern, Gertrude H. Sergievsky Center, 630 West 168th Street, New York, NY, 10032. E-mail: ys11@columbia.edu