Epidemiology and Infection



Smoking and polymorphisms of fucosyltransferase gene Le affect success of H. pylori eradication with lansoprazole, amoxicillin, and clarithromycin


K. MATSUO a1a5c1, N. HAMAJIMA a1, Y. IKEHARA a2, T. SUZUKI a3, T. NAKAMURA a3, A. MATSUURA a3, K. TAJIMA a1 and S. TOMINAGA a4
a1 Division of Epidemiology and Prevention, Nagoya, Japan
a2 Division of Oncological Pathology, Nagoya, Japan
a3 Department of Gastroenterology, Nagoya University, Japan
a4 Aichi Cancer Center, Nagoya, Japan
a5 Nagoya University Graduate School of Medicine, Nagoya, Japan

Abstract

Identification of factors influencing success of Helicobacter pylori (HP) eradication is important for clinical practice. We have prospectively conducted an HP eradication study in the Aichi Cancer Center with a total of 142 patients available for analysis. The overall success rate was 61·3% (95% confidence interval 52·7–69·3%). Smoking during the medication for eradication significantly decreased the success rate (42·9%), whereas smoking cessation during the treatment was associated with a similar rate as for non-smokers (66·7%). We also examined links between an eradication outcome and polymorphisms of Le, Se, IL1A, IL1B, IL1RN and MPO genes, but with one exception none showed any association. The non-functional le allele of Le polymorphisms, leading to decreased expression of Leb antigen to which HP attaches with adhesin, showed a beneficial effect for success. Although further clarification is necessary, our study indicated that smoking cessation and Le gene polymorphisms may affect the success rate of HP eradication.

(Accepted October 31 2002)


Correspondence:
c1 Author for correspondence: Division of Epidemiology and Prevention, 1-1 Kanokoden, Chikusa-ku, Nagoya, Japan 464-8681.


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