Reviews in Clinical Gerontology

As this article doesn't contain an abstract, the image below is necessary to enable the article to be indexed by certain search engines. The resolution of the full-text PDF is much higher than that shown here.

Biological Gerontology

The early environment, developmental plasticity and aging

Avan Aihie  Sayer  a1 c1 and David  Barker  a1
a1 MRC Environmental Epidemiology Unit, University of Southampton, Southampton, UK.

Darwin described how animal populations have two adaptation strategies: natural selection based on genetic variation acting over many generations, and developmental plasticity acting within the lifetime of an individual. The contribution of these processes can be difficult to distinguish at the individual level, and the relevance of human developmental plasticity to aging and health in later life is only now being recognized. The formal definition of developmental plasticity is ‘the ability of a single genotype to produce more than one alternative form of structure, physiological state or behaviour in response to environmental conditions’. As an alternative to adaptation to changing environments through genetic diversification, living things have evolved plastic responses. This enables the production of phenotypes that are better suited to their environment than would be possible if the same phenotype was produced regardless of environmental conditions

c1 Address for correspondence: A Aihie Sayer, MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD.