Journal of the International Neuropsychological Society



Performance monitoring, error processing, and evaluative control following severe TBI


MICHAEL J.  LARSON  a1 , DAVID A.S.  KAUFMAN  a1 , ILONA M.  SCHMALFUSS  a2 a3 and WILLIAM M.  PERLSTEIN  a1 a4 a5 c1
a1 Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida
a2 North Florida/South Georgia Veterans Administration Hospital, Gainesville, Florida
a3 Department of Medicine, University of Florida, Gainesville, Florida
a4 Department of Psychiatry, University of Florida, Gainesville, Florida
a5 The McKnight Brain Institute, University of Florida, Gainesville, Florida

Article author query
larson mj   [PubMed][Google Scholar] 
kaufman da   [PubMed][Google Scholar] 
schmalfuss im   [PubMed][Google Scholar] 
perlstein wm   [PubMed][Google Scholar] 

Abstract

Patients with severe traumatic brain injury (TBI) often demonstrate impairments in performance monitoring—an evaluative control process that can be measured using the error-negativity/error-related negativity (Ne/ERN) and post-error positivity (Pe). The Ne/ERN and Pe are event-related potential (ERP) components generated following errors, with current theories suggesting the Ne/ERN reflects automatic performance monitoring and the Pe reflects error processing and awareness. To elucidate the electrophysiological mechanisms of performance monitoring deficits following severe TBI, behavioral and ERP measurements were obtained, whereas participants with severe TBI and neurologically-healthy comparison participants performed a modified color-naming version of the Stroop task. Behaviorally, both groups demonstrated robust response-time (RT) and error-rate interference. Participants with TBI exhibited generalized RT slowing; no significant between-groups interactions were present for RTs or error rates. ERP results indicate Ne/ERN amplitude was attenuated in participants with TBI, whereas the pattern of Pe amplitude did not clearly differentiate groups. Findings suggest the Ne/ERN as a potential electrophysiological marker of evaluative control/performance monitoring impairment following TBI. Implications for future research and potential clinical application as well as potential limitations in conducting electrophysiological research in neurologically-impaired populations are discussed. (JINS, 2007, 13, 961–971.)

(Received September 14 2006)
(Revised May 22 2007)
(Accepted May 22 2007)


Key Words: Traumatic brain injury; Event-related potentials; Error-related negativity; Stroop; Cognitive control; Error monitoring.

Correspondence:
c1 Correspondence and reprint requests to: William M. Perlstein, Ph.D., Department of Clinical and Health Psychology, HSC Box 100165, University of Florida, Gainesville, FL 32610. E-mail: wmp@phhp.ufl.edu