CJO - Abstract - Inflammation, obesity and comorbidities: the role of diet

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    Inflammation, obesity and comorbidities: the role of diet
    Mónica Bulló, Patricia Casas-Agustench, Pilar Amigó-Correig, Javier Aranceta and Jordi Salas-Salvadó (2007).
    Public Health Nutrition, Volume 10, Issue 10A, October 2007 pp 1164-1172 http://journals.cambridge.org/action/displayAbstract?aid=1344648

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Public Health Nutrition (2007), 10 : 1164-1172 Cambridge University Press
doi:10.1017/S1368980007000663 (About doi)
Published online by Cambridge University Press 28 Sep 2007
 
Cambridge Journals Online - CUP Full-Text Page
Public Health Nutrition (2007), 10:1164-1172 Cambridge University Press
Copyright © The Authors 2007
doi:10.1017/S1368980007000663

Original Article

Inflammation, obesity and comorbidities: the role of diet

Mónica Bullóa1, Patricia Casas-Agustencha1, Pilar Amigó-Correiga1, Javier Arancetaa2 and Jordi Salas-Salvadóa1 c1

a1 Human Nutrition Unit, Hospital Universitari de Sant Joan, Departament de Bioquímica i Biotecnologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, C/Sant Llorenç, 21 43201 Reus, Spain
a2 Departamento de Medicina Preventiva y Salud Pública, Universidad de Navarra, Navarra, Spain
Article author query
bulló m PubMed  Google Scholar
casas-agustench p PubMed  Google Scholar
amigó-correig p PubMed  Google Scholar
aranceta j PubMed  Google Scholar
salas-salvadó j PubMed  Google Scholar

Abstract

The adipocyte metabolism has been shown to change during the fat enlargement process associated to obesity. Several procoagulant proteins such as plasminogen activator inhibitor type 1, tissue factor or factor VII and also inducible nitric oxide synthase show higher expression in adipose tissue of obese people in comparison to lean. This overexpression could explain at least a part of the atherogenic and cardiovascular risk associated with obesity.

In addition to cytokine secretion, many other features have been observed to be common to adipocyte and monocyte/macrophage lines: for example, phagocytic and microbicidal activities, and possibly a cellular plasticity of adipose precursors.

Overweight and obesity are associated with an increased risk of such metabolic abnormalities as dyslipidemia, hypertension or type 2 diabetes mellitus and cardiovascular diseases, common features of the metabolic syndrome. Initially, insulin resistance or hyperinsulinemia was suggested as the origin of these abnormalities. More recent studies indicate that adipokynes have an important role in obesity-associated metabolic complications, and suggest that chronically elevated local or systemic concentrations of adipokynes contribute to the development of complications associated with obesity and metabolic syndrome.

Considering all the evidence relating to diet and inflammation, the best diet for protecting against the metabolic derangements associated with obesity and metabolic syndrome would be high in fibre-rich cereals, fruit, vegetables, fish, virgin olive oil and nuts; moderate in wine; and low in meat, processed meat foods and trans-fatty acids.

(Received November 22 2006)

(Accepted December 11 2006)

Key Words: Inflammation; Obesity; Metabolic syndrome; Diet

Correspondence:

c1 Corresponding author: Email jordi.salas@urv.cat

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