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Nitazoxanide in the treatment of Ascaris lumbricoides in a rural zone of Colima, Mexico

Published online by Cambridge University Press:  01 September 2007

M.L. Galvan-Ramirez ,
N. Rivera ,
M.E. Loeza ,
X. Avila ,
J. Acero ,
R. Troyo  and
R. Bernal
M.L. Galvan-Ramirez
Affiliation:
Laboratorio de Fisiología, Centro Universitario en Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
N. Rivera
Affiliation:
Laboratorio de Fisiología, Centro Universitario en Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
M.E. Loeza
Affiliation:
Laboratorio de Fisiología, Centro Universitario en Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
X. Avila
Affiliation:
Laboratorio de Fisiología, Centro Universitario en Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
J. Acero
Affiliation:
Laboratorio de Fisiología, Centro Universitario en Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
R. Troyo
Affiliation:
Laboratorio de Fisiología, Centro Universitario en Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
R. Bernal*
Affiliation:
Laboratorio de Parasitología y Micología, Hospital Infantil de Mexico Federico Gómez, >MéxicoD.F.
*
*Fax +52 5761 80 01 E-mail: bernalhim@yahoo.com.mx
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Abstract

Intestinal parasites in Mexico are an endemic problem. A study was conducted in children, teenagers and adults in a rural community in Colima, Mexico to examine the prevalence and intensity of Ascaris lumbricoides infection and to evaluate the parasitological and clinical efficacy of nitazoxanide (NTZ). Two hundred and eighty children, teenagers and adults participated in this study. Parasitological diagnosis from faeces was confirmed by three consecutive stool samples using the floatation concentration Faust method. Egg counts were performed as described by the Kato–Katz technique before and after treatment. A questionnaire was systematically applied to obtain information about socio-economic status and hygienic habits. One hundred and six participants (38%) were diagnosed as harbouring intestinal parasites, and 86 of them (81%) were infected with A. lumbricoides. All patients with ascariasis infections underwent a complete physical examination before and after NTZ treatment. NTZ resolved 88% of the ascariasis cases, with a 89% clinical efficacy, and there was a 97.5% reduction in the levels of morbidity. The most intense infections for A. lumbricoides were found in housewives, and statistically significant associations were found between ascariasis and the absence of drainage and living in houses with dirt floors.

Type
Research Papers
Information
Journal of Helminthology , Volume 81 , Issue 3 , September 2007 , pp. 255 - 259
Copyright
Copyright © Cambridge University Press 2007

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