Fetal and Maternal Medicine Review

Research Article

Infection and premature rupture of the membranes

Kyung Seoa1 c1, James A McGregora1 and Janice I Frencha1

a1 Department of Obstetrics and Gynecology, University of Colorado Health Science Center, Denver, Colorado, USA

Premature rupture of the membranes (PROM) and preterm birth

Preterm birth remains a paramount problem in health care worldwide. In the USA, approximately 6–10% of births occur preterm.1–3 Gestational age at birth is the most important determinant of an infant's morbidity and mortality. Preterm infants account for approximately 75% of neonatal deaths,3–5 as well as incalculable direct and indirect financial costs and morbidity.6–9

Correspondence:

c1 Kyung Seo, Department of Obstetrics and Gynecology, University of Colorado Health Science Center, Denver, Colorado, USA.