Parasitology



Estimating the distribution of worm burden and egg excretion of Schistosoma japonicum by risk group in Sichuan Province, China


A.  HUBBARD  a1 , S.  LIANG  a1 a2 , D.  MASZLE  a1 , D.  QIU  a2 , X.  GU  a2 and R. C.  SPEAR  a1 c1
a1 Center for Occupational and Environmental Health, School of Public Health, University of California, Berkeley, CA 94720-7360, USA
a2 Sichuan Institute of Parasitic Disease, 10 University Road, Chendgdu, Sichuan 610041, P.R. China

Article author query
hubbard a   [PubMed][Google Scholar] 
liang s   [PubMed][Google Scholar] 
maszle d   [PubMed][Google Scholar] 
qiu d   [PubMed][Google Scholar] 
gu x   [PubMed][Google Scholar] 
spear r   [PubMed][Google Scholar] 

Abstract

During autumn 2000 an extensive cross-sectional survey of the prevalence of Schistosomiasis japonicum was conducted among about 4000 villagers within 20 villages in the Anning River Valley located in the southwestern Sichuan Province. Two procedures were used to assess infection status, the Kato-Katz thick smear procedure and a miracidia hatch test. Whereas the Kato-Katz procedure provides information on both prevalence and intensity, the hatch test provides only prevalence data, albeit on a much larger volume of stool. In addition, we performed Kato-Katz smears for 15 consecutive samples on a subset of 15 individuals. The proportion of both hatch-test and Kato-Katz positive individuals in the larger cross-sectional survey was 25%. The goal of the study was to estimate both the egg and worm distributions among risk groups using both the hatch and Kato-Katz tests from the cross-sectional data and the repeated Kato-Katz smears from the longitudinal data sets. As a prelude to parameter estimation, individuals were classified into risk groups by natural village and occupation; the proportion of Kato-Katz positive subjects among the risk groups varied from 10% to 60%. We used the statistical model of de Vlas et al. (1992) and Bayesian techniques to derive both estimates of and inference about the worm and egg distribution parameters. The parameter estimates imply (1) similar eggs per gram stool (e.p.g.) per worm pair compared with earlier estimates, (2) a range of worm burdens among the risk groups and (3) estimates of risk heterogeneity within groups is sensitive to prior information on the within-person variability in egg excretion.

(Received December 29 2001)
(Revised April 22 2002)
(Accepted April 26 2002)


Key Words: schistosomiasis; parasite burden; Bayesian estimation.

Correspondence:
c1 Corresponding author: School of Public Health, 140 Warren Hall, University of California, Berkeley, CA 94720-7360, USA. Tel: +510 642 0761. Fax: +510 642 5815. E-mail: spear@uclink4.berkeley.edu


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