Paneth and intermediate cell hyperplasia induced in mice by helminth infections
Hyperplasia of Paneth and intermediate cells is a recently described component of the response of the small intestine of mice to infection with the nematode Trichinella spiralis. To investigate whether this hyperplasia is parasite specific or represents a generic intestinal response to infection, mice were infected with T. spiralis, Nippostrongylus brasiliensis, Heligmosomoides polygyrus or Schistosoma mansoni and tissue samples taken at various time-points post-infection to determine Paneth and intermediate cell numbers. All infections induced Paneth and intermediate cell hyperplasia, but the patterns of response varied between the parasite species concerned, reflecting differences in their relationships with the host. Increases in the numbers of these cells appeared to correlate with known patterns of T-helper-2 immune responses.(Received January 26 2002)
(Revised April 23 2002)
(Accepted April 23 2002)
Key Words: Paneth cells; intermediate cells; T cell immunity; Trichinella spiralis; Nippostrongylus brasiliensis; Heligmosomoides polygyrus; Schistosoma mansoni.
c1 Corresponding author: School of Life and Environmental Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK. Tel: +44 115 9513232. Fax: +44 115 9513252. E-mail: [email protected]
p1 Present address: Department of Medical Microbiology, Windeyer Institute, University College London, London, UK.