Epidemiology and Infection

Contribution of RSV to bronchiolitis and pneumonia-associated hospitalizations in English children, April 1995–March 1998

B.  MÜLLER-PEBODY  a1 a3, W. J.  EDMUNDS  a1, M. C.  ZAMBON  a2, N. J.  GAY  a1 and N. S.  CROWCROFT  a1 c1
a1 PHLS, Communicable Disease Surveillance Centre, Immunisation Division, 61 Colindale Avenue, London NW9 5EQ, UK
a2 PHLS, Central Public Health Laboratory, Enteric, Respiratory and Neurological Virus Laboratory, London, UK
a3 Statens Serum Institut, Department of Microbiological Research, Copenhagen, Denmark


Estimates of the number of hospitalizations attributable to specific pathogens are required to predict the potential impact of vaccination. All hospital admissions for lower respiratory tract infection (LRI) in children <5 years in England in 1995–8 were reviewed. Most admissions (76.8%) were not associated with specific organisms. Seasonality in pathogens that cause bronchiolitis and pneumonia was used to predict the proportion of cases with unspecified aetiology attributable to different organisms using multiple linear regression. Of 12298 admissions for LRI, 17.5% were due to RSV infection. An estimated 74.8% (95% CI, 72.0–77.7%) of ‘unspecified bronchiolitis’ admissions and 16.3% (95% CI, 13.7–18.8%) of ‘unspecified pneumonia’ admissions were RSV related. The total mean annual incidence of hospital admissions attributable to RSV is 28.3/1000 children <1 year of age, and 1.3/1000 children 1–4 years old. The greater burden of RSV infection than indicated through discharge data is revealed through applying simple statistical methods.

(Accepted March 13 2002)

c1 Author for correspondence.