Cushing' syndrome due to the abuse of betamethosone nasal drops

D. J. Stevens

doi:10.1017/S0022215100104566

Abstract

Cushing's syndrome due to the abuse of Betamethasone nasal drops has not been described before. This report presents such a case and emphasises the care which oe must take in prescribing topical sterioids.

References

Aaron, T. H. and Muttitt, E. L. C. (1965) Effect of intranasal dexamethasone on the adrenal function of patients with perennial allergic rhinitis. Annals of Allergy, 23: 100–102.Google Scholar PubMed

Austin, R. and Parish, P. (1976) Journal of the Royal College of General Practitioners, 27, Supplement 1: 44–49.Google Scholar

Champion, P. K. Jr (1974) Cushings Syndrome secondary to abuse of dexamethasone nasal spray. Archives of Internal Medicine, 134: 750–751.CrossRef Google Scholar PubMed

Dominguez Ortega, L. and Gil Grande, R. (1979) Cushing's syndrome due to abuse of dexamethasone nasal spray. Lancet, 11: 96.CrossRef Google Scholar

Drury, V. W. M. (1982) Journal of the Royal College of Practitioners, 32: 42–45.Google Scholar

Michels, M. I. (1967) Adrenal suppression and intranasally applied steroids. Annals of Allergy, 25: 569–574.Google Scholar PubMed

Kimmerle, R. and Rolla, A. R. (1985) Iatrogenic Cushing's syndrome due to dexamethasone nasal drops. The American Journal of Medicine, 79: 535–537.CrossRef Google Scholar PubMed

Crossref Citations

This article has been cited by the following publications. This list is generated based on data provided by Crossref.

Flynn, M. D. Beasley, P. and Tooke, J. E. 1992. Adrenal suppression with intranasal betamethasone drops. The Journal of Laryngology & Otology, Vol. 106, Issue. 9, p. 827.

Drake-Lee, A. B. 1994. Immunology of ENT Disorders. p. 151.

Scadding, GK Darby, YC and Austin, CE 1994. Effect of short‐term treatment with fluticasone propionate nasal spray on the response to nasal allergen challenge.. British Journal of Clinical Pharmacology, Vol. 38, Issue. 5, p. 447.

Daman Willems, C. E. Dinwiddie, R. Grant, D. B. Rivers, R. P A. and Zahir, M. 1994. Temporary inhibition of growth and adrenal suppression associated with the use of steroid nose drops. European Journal of Pediatrics, Vol. 153, Issue. 9, p. 632.

Nutting, C M and Page, S R 1995. Iatrogenic Cushing’s syndrome due to nasal betamethasone: a problem not to be sniffed at!. Postgraduate Medical Journal, Vol. 71, Issue. 834, p. 231.

Mygind, Niels and Lund, Valerie 1996. Topical Corticosteroid Therapy of Rhinitis. Clinical Immunotherapeutics, Vol. 5, Issue. 2, p. 122.

Golding-Wood, David G. Holmstrom, Mats Darby, Yvonne Scadding, Glenis K. and Lund, Valerie J. 1996. The treatment of hyposmia with intranasal steroids. The Journal of Laryngology & Otology, Vol. 110, Issue. 2, p. 132.

Gazis, A. G. Homer, J. J. Henson, D. B. Page, S. R. and Jones, N. S. 1999. The effect of six weeks topical nasal betamethasone drops on the hypothalamo-pituitary-adrenal axis and bone turnover in patients with nasal polyposis. Clinical Otolaryngology and Allied Sciences, Vol. 24, Issue. 6, p. 495.

Bousquet, Jean van Cauwenberge, Paul and Khaltaev, Nikolai 2001. Allergic Rhinitis and Its Impact on Asthma. Journal of Allergy and Clinical Immunology, Vol. 108, Issue. 5, p. S147.

Caldas, Dayse and Schrank, Yolanda 2001. Síndrome de Cushing por uso abusivo de descongestionante nasal contendo dexametasona: Relato de caso. Revista Brasileira de Otorrinolaringologia, Vol. 67, Issue. 6, p. 868.

Gill, Geoffrey Swift, Andrew Jones, Alan Strain, David and Weston, Philip 2001. Severe Adrenal Suppression by Steroid Nasal Drops. Journal of the Royal Society of Medicine, Vol. 94, Issue. 7, p. 350.

Fowler, P.D. Gazis, A.G. Page, S.R. and Jones, N.S. 2002. A randomized double-blind study to compare the effects of nasal fluticasone and betamethasone on the hypothalamo-pituitary-adrenal axis and bone turnover in patients with nasal polyposis. Clinical Otolaryngology and Allied Sciences, Vol. 27, Issue. 6, p. 489.

Salib, Rami Jean and Howarth, Peter Hugo 2003. Safety and Tolerability Profiles of Intranasal Antihistamines and Intranasal Corticosteroids in the Treatment of Allergic Rhinitis. Drug Safety, Vol. 26, Issue. 12, p. 863.

Ozon, A. Cetinkaya, S. Alikasifoglu, A. Gonc, E.N. Şen, Y. and Kandemir, N. 2007. Inappropriate Use of Potent Topical Glucocorticoids in Infants. Journal of Pediatric Endocrinology and Metabolism, Vol. 20, Issue. 2,

Poetker, David M. and Reh, Douglas D. 2010. A Comprehensive Review of the Adverse Effects of Systemic Corticosteroids. Otolaryngologic Clinics of North America, Vol. 43, Issue. 4, p. 753.

Aouad, Rony K. and Chiu, Alexander G. 2011. State of the Art Treatment of Nasal Polyposis. American Journal of Rhinology & Allergy, Vol. 25, Issue. 5, p. 291.

Snidvongs, Kornkiat Pratt, Eleanor Chin, David Sacks, Raymond Earls, Peter and Harvey, Richard J. 2012. Corticosteroid nasal irrigations after endoscopic sinus surgery in the management of chronic rhinosinusitis. International Forum of Allergy & Rhinology, Vol. 2, Issue. 5, p. 415.

Dow, Adrienne Yu, Run and Carmichael, John 2013. Too little or too much corticosteroid? Coexisting adrenal insufficiency and Cushing's syndrome from chronic, intermittent use of intranasal betamethasone. Endocrinology, Diabetes & Metabolism Case Reports, Vol. 2013, Issue. ,

Sampieri, Gianluca Namavarian, Amirpouyan Lee, John J. W. Hamour, Amr F. and Lee, John M. 2022. Hypothalamic‐pituitary‐adrenal axis suppression and intranasal corticosteroid use: A systematic review and meta‐analysis. International Forum of Allergy & Rhinology, Vol. 12, Issue. 1, p. 11.

Kothiwala, Mamta Samdani, Sunil Grover, Mohnish and Gurjar, Vishram 2022. Efficacy of Topical High Volume Budesonide Nasal Irrigation in Post FESS Patients of Chronic Rhinosinusitis With or Without Nasal Polyposis. Indian Journal of Otolaryngology and Head & Neck Surgery, Vol. 74, Issue. S2, p. 1399.

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Cushing' syndrome due to the abuse of betamethosone nasal drops

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This article has been cited by the following publications. This list is generated based on data provided by Crossref.

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Cushing' syndrome due to the abuse of betamethosone nasal drops

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