White matter microstructural abnormalities in late-life depression
Objective: To evaluate the location and the degree of white matter damage in late-life depression using diffusion tensor imaging (DTI).
Methods: Thirty-one patients with late-life depression and 15 healthy volunteers matched for age, gender and years of education received conventional MRI (magnetic resonance imaging) and MR-diffusion tensor scanning. The fractional anisotropy (FA) values of white matter were measured respectively in frontal and temporal regions and the corpus callosum.
Results: FA values were significantly decreased in the frontal (superior and middle frontal gyrus), and temporal (right parahippocampal gyrus) regions of elderly patients with depression compared with healthy controls.
Conclusion: Microstructural changes in the frontal (superior and middle frontal gyrus) and temporal (right parahippocampal gyrus) areas are associated with late-life depression.(Received March 15 2006)
(returned for revision April 11 2006)
(revised version received November 27 2006)
(Accepted November 28 2006)
(Published Online March 9 2007)
Key Words: late-life depression; MR-diffusion tensor imaging; fractional anisotropy.
c1 Correspondence should be addressed to: Xin Yu, Institute of Mental Health, Peking University, Huayuanbeilu 51, Beijing 100083, China. Phone: +86 1082801999; Fax: +86 1062026310. Email: email@example.com.