Hostname: page-component-8448b6f56d-42gr6 Total loading time: 0 Render date: 2024-04-23T07:32:38.830Z Has data issue: false hasContentIssue false
  • English
  • Français

Khat and oral cancer

Published online by Cambridge University Press:  29 June 2007

Hissam E. Soufi ,
Mohan Kameswaran  and
Tarek Malatani
Hissam E. Soufi
Affiliation:
Department of Medicine, Abha Branch, College of Medicine, Abha, Saudi Arabia.
Mohan Kameswaran*
Affiliation:
Department of ENT, Abha Branch, College of Medicine, Abha, Saudi Arabia.
Tarek Malatani
Affiliation:
Department of Surgery, King Saud University, Abha Branch, College of Medicine, Abha, Saudi Arabia.
*
Dr M. Kameswaran, Department of ENT, College of Medicine, Abha Branch, Abha, PO Box 641, Saudi Arabia
Get access Rights & Permissions [Opens in a new window]

Abstract

Oral cancers in the Asir region of Saudi Arabia have been observed to occurmostly among patients who have been long-term khat users. In a survey that reviewed cancers for the past two years there were 28 head and neck cancer patients, 10 of whom presented with a history of having chewed khat. One of these was a case of metastatic cervical lymph node and unknown primary, one was a parotid tumour, and the remaining eight presented with oral cancers. All were non-smoking khat chewers and all of them had used itover a period of 25 years or longer. We conclude that this strong correlation between khat chewing and oral cancer warrants attention.

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 105 , Issue 8 , August 1991 , pp. 643 - 645
Copyright
Copyright © JLO (1984) Limited 1991

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Al-Meshal, I. A., Tariq, M., Hifnawy, M. S., Mekkawi, A. G., Muhtadi, F. J. (1983) Characterization and evaluation of Saudi Arabian Khat. Abstracts, First International Conference on Khat, ed. by InternationalCouncil on Alcohol and Addictions,Lausanne,Switerland, p 110–134.Google Scholar
Al-Meshal, I. A., Ageel, A. M., Parmar, N. S., Tariq, M. (1985) Catha edulis (Khat): use, abuse and current status of scientific knowledge. Fitoterapia, 56: 131–152.Google Scholar
Al-Ahdal, M. N., McGarry, T. J., Hannan, M. A. (1988) Cytotoxicity of khat (Catha edulis) extract on cultured mammalian cells: effects on macromolecule biosynthesis. Mutation Research [NNA], 204: 317–322.CrossRefGoogle ScholarPubMed
Elmi, A. (1983) The chewing of khat in Somalia. Journalof Ethnophamacology, 8: 163–176.CrossRefGoogle ScholarPubMed
Hammouda, E. (1971) Effect of khat extract, D-cycloserine and thalidomide on ribonucleic acid (RNA) of the neurons of 7 and 19 days chick embryo. Bulletin of the Faculty of Science, Riyadh University, 3: 99–112.Google Scholar
Hammouda, E. M. (1972) Effect of khat extracts, D-cycloserine and thalidomide on deoxyribonucleic acid (DNA) of the neurones of 7 and 19 days chick embryo. Bulletin of the Faculty of Science, Riyadh University, 3: 63–76.Google Scholar
Hammouda, E. M. (1978) Effects of dietary khat extract on the testis of the white leghorn Gallus domesticus. Bulletin of the Faculty of Science, King Abdulaziz University, Jeddah, 2: 17–22.Google Scholar
Hannan, M. A., Aboul-Enein, H. Y., Dakan, A. A. (1985) Histidine reversion in ames’ salmonella strains induced by extracts of ‘khat’–a substance of abuse. Research Communications in Substances of Abuse, 6: 179–188.Google Scholar
Jansson, T., Kristiansson, B., Qirbi, A. (1988a) Effects of khat on maternal food intake, maternal weight gain and fetal growth in the late-pregnant guinea pig. Journal of Ethnopharmacology [K8T], 23: 11.CrossRefGoogle ScholarPubMed
Jansson, T., Kristiansson, B., Qirbi, A. (1988b) Effects of khat on uteroplacental blood flow in awake, chronically catheterized, late-pregnant guinea pigs. Journal of Ethnopharmacology [K8T], 23: 19–26.CrossRefGoogle ScholarPubMed
Kalix, P., Braenden, O. (1985) Pharmacological aspects ofthe chewing of khat leaves. Pharmacological Reviews, American Society for Pharmacology and Experimental Therapeutics, 37: 149–163.Google Scholar
Soufi, H. E., Afifi, M. M., Alshehry, M. R. G. (1989)Catha edulis abuse with a case report. In VIII World Congress of Psychiatry Abstracts, Psychiatry Today (Stefanis, C. N., Soldatos, C. R., Rabavilas, A. D., eds.) Excerpta Medica International Congress Series 899 Amsterdam, 542.Google Scholar
Tariq, M., Ageel, A. M., Parmar, N. S., Al-Meshal, I. A. (1984a) The pharmacological investigation of the Saudi Arabia variant of Catha edulis (Khat). Fitoterapia, 55: 195–199.Google Scholar
Tariq, M., Parmer, N. S., Ageel, A. M., Meshal, I. A., Abu-Jayyab, A. (1984b) The gastric anti-ulcer activity of khat (Catha edulis Forsk): Investigations on its flavonoid fraction. Research Communications in Substance Abuse. Vol.5, PJD Publications Limited, New York, USA, 157–160.Google Scholar