D-KEFS Trail Making Test performance in patients with lateral prefrontal cortex lesions
This study evaluated cognitive set-shifting in 12 patients with focal lesions in the lateral prefrontal cortex (LPC) by examining their performance on the Trail Making Test from the Delis-Kaplan Executive Function System (D-KEFS). Patients with LPC lesions performed significantly worse than controls on the D-KEFS Trail Making Test on the Letter Sequencing, Number-Letter Switching (set-shifting), and Motor Speed conditions. Patients with LPC lesions performed significantly more slowly on the Number-Letter Switching condition even after controlling for performance on the four baseline conditions of the test. In addition, patients with LPC lesions exhibited significantly elevated error rates on the Number-Letter Switching condition. Results suggest that LPC lesions can lead to impaired cognitive set-shifting on a visual-motor sequencing task. (JINS, 2007, 13, 704–709.)(Received October 2 2006)
(Revised February 13 2007)
(Accepted February 14 2007)
Key Words: Executive; Frontal; Set-shifting; D-KEFS; Trail making; Lesion.
c1 Correspondence and reprint requests to: Brian Yochim, Ph.D., Assistant Professor, Department of Psychology, University of Colorado at Colorado Springs, 1420 Austin Bluffs Parkway, Colorado Springs, CO 80933-7150. E-mail: firstname.lastname@example.org