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Schizotypal disorder and schizophrenia: A profile analysis of neuropsychological functioning in Japanese patients

Published online by Cambridge University Press:  18 May 2007

MIÉ MATSUI
Affiliation:
Department of Neuropsychology and Neuropsychiatry, Graduate School of Medicine, University of Toyama, Toyama, Japan Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan
HIROMI YUUKI
Affiliation:
Department of Neuropsychology and Neuropsychiatry, Graduate School of Medicine, University of Toyama, Toyama, Japan
KANADE KATO
Affiliation:
Department of Neuropsychology and Neuropsychiatry, Graduate School of Medicine, University of Toyama, Toyama, Japan
AI TAKEUCHI
Affiliation:
Section of Liaison Psychiatry and Palliative Medicine, School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
SHIMAKO NISHIYAMA
Affiliation:
Department of Neuropsychology and Neuropsychiatry, Graduate School of Medicine, University of Toyama, Toyama, Japan Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan
WARREN B. BILKER
Affiliation:
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
MASAYOSHI KURACHI
Affiliation:
Department of Neuropsychology and Neuropsychiatry, Graduate School of Medicine, University of Toyama, Toyama, Japan Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan

Abstract

This study compares neuropsychological functioning in a Japanese schizophrenia spectrum disorder group and a group of healthy Japanese volunteers. Participants were 37 patients diagnosed with schizophrenia, 28 schizotypal patients, and 99 psychiatrically-normal volunteers. A wide range of cognitive measures were examined. All participants completed a Japanese version of a neuropsychological battery assessing executive function, working memory, processing speed, language, verbal memory, and spatial organization. Comparisons of neuropsychological function demonstrated similarities and differences between patients diagnosed with schizotypal disorder and those diagnosed with schizophrenia. Impairments in verbal memory, language, and processing speed were common to both patient groups and may represent a vulnerability to schizophrenia. Impairments in aspects of working memory, spatial organization and executive function were preferentially observed in schizophrenia and may be features of the overt manifestation of psychosis. Possible differences in the contributions of prefrontal and temporolimbic structures provide direction for further studies. (JINS, 2007, 13, 672–682.)

Type
Research Article
Copyright
© 2007 The International Neuropsychological Society

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