The Journal of Laryngology & Otology

Main Articles

The effect of cetirizine on symptoms and signs of nasal polyposis

Rolf Hayea1 c1, Jens P. Aanesena1, Bernard Burtina2, Fergal Donnellya2 and Christian Dubya2

a1 Department of Otolaryngology, Rikshospitalet, Oslo, Norway

a2 UCB Pharma, Braine L'Alleud, Belgium

Abstract

Forty-five patients with residual or recurrent nasal polyposis after ethmoidectomy were treated with either cetirizine at twice the daily recommended (20 mg) dose or placebo for three months. The number and size of polyps remained unchanged during the study period. Cetirizine was found to reduce nasal sneezing and rhinorrhoea effectively. The drug also had a beneficial effect on nasal obstruction in the latter part of the study. The side effects of 20 mg (double the recommended daily adult dose) of cetirizine were few and comparable to placebo.

(Accepted July 09 1998)

Correspondence:

c1 Address for correspondence: Rolf Haye, M.D., Department of Otolaryngology, Rikshospitalet, 0027 Oslo, Norway. Fax: +47 – 22 86 96 35