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New inflammatory parameters in laryngopharyngeal reflux

Published online by Cambridge University Press:  08 August 2016

H Arslan ,
T Çandar ,
S Kuran ,
Ş H Akmansu  and
S Kocatürk
H Arslan*
Affiliation:
Department of Otorhinolaryngology, Ufuk University Medical School, Ankara, Turkey
T Çandar
Affiliation:
Department of Biochemistry, Ufuk University Medical School, Ankara, Turkey
S Kuran
Affiliation:
Department of Gastroenterology, Çukurova University Medical School, Adana, Turkey
Ş H Akmansu
Affiliation:
Department of Otorhinolaryngology, Ufuk University Medical School, Ankara, Turkey
S Kocatürk
Affiliation:
Department of Otorhinolaryngology, Ufuk University Medical School, Ankara, Turkey
*
Address for correspondence: Dr Hande Arslan, Department of Otorhinolaryngology, Ufuk University Medical School, Balgat 06520, Ankara, Turkey E-mail: handearslan5@yahoo.com
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Abstract

Objectives:

To investigate new inflammatory markers in patients with laryngopharyngeal reflux and determine whether these inflammatory parameters change in response to laryngopharyngeal reflux treatment.

Methods:

Complete blood count was evaluated to obtain platelet count and mean platelet volume and calculate neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio. Laryngopharyngeal reflux patients underwent three-month lansoprazole treatment.

Results:

The study included 45 laryngopharyngeal reflux patients (9 men (20 per cent); mean age, 37.4 ± 11.6 years) and 35 healthy age- and sex-matched controls (7 men (20 per cent); mean age, 38.6 ± 8.9 years). The study group had significantly higher platelet-to-lymphocyte ratios and lower mean platelet volumes than the control group (p = 0.004 and p = 0.047, respectively). There was a significant correlation between platelet-to-lymphocyte ratios and initial inflammatory symptoms (reflux symptom index, p = 0.025; reflux finding score, p = 0.013). There was also a significant correlation between mean platelet volume increase and symptom resolution in the first and third months of treatment (p = 0.04 and p = 0.03, respectively).

Conclusion:

Platelet-to-lymphocyte ratio, a new inflammatory marker of chronic inflammation, was significantly higher in laryngopharyngeal reflux patients. Moreover, these patients had significantly lower mean platelet volume values, which increased with post-treatment symptom improvement.

Keywords

Laryngopharyngeal RefluxNeutrophilLymphocytePlateletMean Platelet Volume
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 130 , Issue 9 , September 2016 , pp. 878 - 882
Copyright
Copyright © JLO (1984) Limited 2016 

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