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Head and neck sarcomas: clinical and histopathological presentation, treatment modalities, and outcomes

Published online by Cambridge University Press:  01 August 2016

M Stavrakas ,
I Nixon ,
K Andi ,
R Oakley ,
J P Jeannon ,
A Lyons ,
M McGurk ,
T Guerrero Urbano ,
S Thavaraj  and
R Simo
M Stavrakas*
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, Guy's and St Thomas’ NHS Foundation Trust, London, UK
I Nixon
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, Guy's and St Thomas’ NHS Foundation Trust, London, UK
K Andi
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, Guy's and St Thomas’ NHS Foundation Trust, London, UK
R Oakley
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, Guy's and St Thomas’ NHS Foundation Trust, London, UK
J P Jeannon
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, Guy's and St Thomas’ NHS Foundation Trust, London, UK
A Lyons
Affiliation:
Department of Oral and Maxillofacial Surgery, Guy's and St Thomas’ NHS Foundation Trust, London, UK
M McGurk
Affiliation:
Department of Oral and Maxillofacial Surgery, Guy's and St Thomas’ NHS Foundation Trust, London, UK
T Guerrero Urbano
Affiliation:
Department of Clinical Oncology, Guy's and St Thomas’ NHS Foundation Trust, London, UK
S Thavaraj
Affiliation:
Department of Oral and Head and Neck Pathology, Guy's and St Thomas’ NHS Foundation Trust, London, UK
R Simo
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, Guy's and St Thomas’ NHS Foundation Trust, London, UK
*
Address for correspondence: Dr Marios Stavrakas, Department of Otorhinolaryngology Head and Neck Surgery, 3rd Floor Southwark Wing, Guy's Hospital, St Thomas Street, London SE1 9RT, UK E-mail: mstavrakas@doctors.org.uk
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Abstract

Background:

Sarcoma of the head and neck is a rare condition that poses significant challenges in management and often requires radical multimodality treatment.

Objectives:

This study aimed to analyse current clinical presentation, evaluation, management dilemmas and oncological outcomes.

Methods:

Computer records and case notes were analysed, and 39 patients were identified. Variables were compared using Pearson's chi-square test and the log-rank test, while survival outcomes were calculated using the Kaplan–Meier method.

Results:

The histopathological diagnosis was Kaposi sarcoma in 20.5 per cent of cases, chondrosarcoma in 15.3 per cent and osteosarcoma in 10.2 per cent. A range of other sarcomas were diagnosed in the remaining patients. The site of disease was most commonly sinonasal, followed by the oral cavity and larynx.

Conclusion:

Wide local excision with clear resection margins is essential to achieve local control and long-term survival. There is a need for cross-specialty collaboration in order to accrue the evidence which will be necessary to improve long-term outcomes.

Keywords

SarcomaHead And Neck CancerSarcoma ManagementKaposi SarcomaOsteosarcomaChondrosarcoma
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 130 , Issue 9 , September 2016 , pp. 850 - 859
Copyright
Copyright © JLO (1984) Limited 2016 

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