Hostname: page-component-8448b6f56d-wq2xx Total loading time: 0 Render date: 2024-04-19T21:39:44.368Z Has data issue: false hasContentIssue false
  • English
  • Français

Effectiveness of 3 per cent boric acid in 70 per cent alcohol versus 1 per cent clotrimazole solution in otomycosis patients: a randomised, controlled trial

Published online by Cambridge University Press:  01 August 2016

S Romsaithong ,
K Tomanakan ,
W Tangsawad  and
S Thanaviratananich
S Romsaithong
Affiliation:
Department of Otolaryngology, Khon Kaen Hospital, Thailand
K Tomanakan
Affiliation:
Department of Medical Technology, Khon Kaen Hospital, Thailand
W Tangsawad
Affiliation:
Department of Otolaryngology, Khon Kaen Hospital, Thailand
S Thanaviratananich*
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, Khon Kaen University, Thailand
*
Address for correspondence: Dr Sanguansak Thanaviratananich, Department of Otorhinolaryngology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand Fax: +66 43 202 490 E-mail: sanguans@kku.ac.th
Get access Rights & Permissions [Opens in a new window]

Abstract

Objectives:

To compare the clinical effectiveness and adverse events for 3 per cent boric acid in 70 per cent alcohol versus 1 per cent clotrimazole solution in the treatment of otomycosis.

Methods:

A total of 120 otomycosis patients were randomly assigned to receive either 1 per cent clotrimazole solution (intervention group) or 3 per cent boric acid in 70 per cent alcohol (control group) at the Khon Kaen Hospital ENT out-patient department. Treatment effectiveness was determined based on the otomicroscopic absence of fungus one week after therapy, following a single application of treatment.

Results:

After 1 week of treatment, there were data for 109 participants, 54 in the clotrimazole group and 55 in the boric acid group. The absolute difference in cure rates between 1 per cent clotrimazole solution and 3 per cent boric acid in 70 per cent alcohol was 17.9 per cent (95 per cent confidence interval, 2.3 to 33.5; p = 0.028) and the number needed to treat was 6 (95 per cent confidence interval, 3.0 to 43.4). Adverse events for the two agents were comparable.

Conclusion:

One per cent clotrimazole solution is more effective than 3 per cent boric acid in 70 per cent alcohol for otomycosis treatment.

Keywords

Boric AcidsClotrimazoleOtomycosisOtitis ExternaMycosesAntifungal Agents
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 130 , Issue 9 , September 2016 , pp. 811 - 815
Copyright
Copyright © JLO (1984) Limited 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 Moghadam, AY, Asadi, MA, Dehghani, R, Mahmoudabadi, AZ, Rayegan, F, Hooshyar, H et al. Evaluating the effect of a mixture of alcohol and acetic acid for otomycosis therapy. Jundishapur J Microbiol 2010;3:66–70 Google Scholar
2 Munguia, R, Daniel, SJ. Ototopical antifungals and otomycosis: a review. Int J Pediatr Otorhinolaryngol 2008;72:453–9Google Scholar
3 Vennewald, I, Klemm, E. Otomycosis: diagnosis and treatment. Clin Dermatol 2010;28:202–11Google Scholar
4 del Palacio, A, Cuetara, MS, Lopez-Suso, MJ, Amor, E, Garau, M. Randomized prospective comparative study: short-term treatment with ciclopiroxolamine (cream and solution) versus boric acid in the treatment of otomycosis. Mycoses 2002;45:317–28Google Scholar
5 Khan, F, Muhammad, R, Khan, MR, Rehman, F, Iqbal, J, Khan, M et al. Efficacy of topical clotrimazole in treatment of otomycosis. J Ayub Med Coll Abbottabad 2013;25:78–80 Google Scholar
6 Ho, T, Vrabec, JT, Yoo, D, Coker, NJ. Otomycosis: clinical features and treatment implications. Otolaryngol Head Neck Surg 2006;135:787–91Google Scholar
7 Ozcan, KM, Ozcan, M, Karaarslan, A, Karaarslan, F. Otomycosis in Turkey: predisposing factors, aetiology and therapy. J Laryngol Otol 2003;117:39–42 Google Scholar
8Efficacy of Tincture merthiolate vs 3% Boric acid in treatment of otomycosis [in Thai]. In: http://med.mahidol.ac.th/ent/sites/default/files/public/pdf/AbstractPornsilINAL%20otomycosis...pdf [31 May 2015]Google Scholar
9 Kley, E. A contribution to the treatment of otomycoses [in German]. Laryngol Rhinol Otol (Stuttg) 1976;55:765–7Google Scholar
10 Chander, J, Maini, S, Subrahmanyan, S, Handa, A. Otomycosis–a clinico-mycological study and efficacy of mercurochrome in its treatment. Mycopathologia 1996;135:9–12 Google Scholar
11 Hurst, WB. Outcome of 22 cases of perforated tympanic membrane caused by otomycosis. J Laryngol Otol 2001;115:879–80Google Scholar
12 Mgbor, N, Gugnani, HC. Otomycosis in Nigeria: treatment with mercurochrome. Mycoses 2001;44:395–7Google Scholar
13 Ologe, FE, Nwabuisi, C. Treatment outcome of otomycosis in Ilorin, Nigeria. West Afr J Med 2002;21:34–6Google Scholar
14 Jadhav, VJ, Pal, M, Mishra, GS. Etiological significance of Candida albicans in otitis externa. Mycopathologia 2003;156:313–15CrossRefGoogle ScholarPubMed
15 Jackman, A, Ward, R, April, M, Bent, J. Topical antibiotic induced otomycosis. Int J Pediatr Otorhinolaryngol 2005;69:857–60Google Scholar
16 Chalabi, EY, Ahmed, ST. The role of various out patients aural toileting procedures in the treatment of otomycosis. J Zankoy Sulaimani 2010;13:39–48 Google Scholar