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Response to docetaxel and cisplatin induction chemotherapy of locally advanced head and neck squamous cell carcinoma: a multicenter, non-comparative, open-label interventional pilot study

Published online by Cambridge University Press:  26 July 2016

V Noronha ,
C Goswami ,
S Patil ,
A Joshi ,
V M Patil ,
V Murthy ,
S Arya ,
S Juvekar ,
S Goud  and
K Prabhash
V Noronha
Affiliation:
Department of Medical Oncology, Tata Memorial Hospital, Parel, Mumbai, India
C Goswami
Affiliation:
Department of Medical Oncology, B. P. Poddar Hospital and Medical Research Ltd, Kolkata, India
S Patil
Affiliation:
Department of Medical Oncology, HCG Hospital, Bengaluru, Karnataka, India
A Joshi
Affiliation:
Department of Medical Oncology, Tata Memorial Hospital, Parel, Mumbai, India
V M Patil
Affiliation:
Department of Medical Oncology, Tata Memorial Hospital, Parel, Mumbai, India
V Murthy
Affiliation:
Department of Radiation Oncology, Tata Memorial Hospital, Parel, Mumbai, India
S Arya
Affiliation:
Department of Radiodiagnosis, Tata Memorial Hospital, Parel, Mumbai, India
S Juvekar
Affiliation:
Department of Radiodiagnosis, Tata Memorial Hospital, Parel, Mumbai, India
S Goud
Affiliation:
Department of Medical Oncology, HCG Hospital, Bengaluru, Karnataka, India
K Prabhash*
Affiliation:
Department of Medical Oncology, HCG Hospital, Bengaluru, Karnataka, India
*
Address for correspondence: Dr K Prabhash, Department of Medical Oncology, Tata Memorial Hospital, Parel, Mumbai 400012, Maharashtra, India E-mail: kumarprabhashtmh@gmail.com
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Abstract

Background:

Docetaxel, cisplatin plus 5-fluorouracil is an efficacious induction regimen but is more toxic than cisplatin plus 5-fluorouracil. This study aimed to determine whether docetaxel and cisplatin without 5-fluorouracil maintains efficacy while decreasing toxicity.

Methods:

A multicenter non-comparative pilot study of locally advanced squamous cell carcinoma of the head and neck was performed. Patients received primary therapy comprising three cycles of 75 mg/m2 docetaxel and 75 mg/m2 cisplatin followed by concurrent chemoradiotherapy. The primary endpoint was the response rate to the docetaxel and cisplatin induction regimen.

Results:

A total of 26 patients were enrolled: of these, 23 (88.5 per cent) received all three docetaxel and cisplatin cycles. Common grade 3–4 adverse events were febrile neutropenia (19.2 per cent of patients), diarrhoea (19.2 per cent) and non-neutropenic infection (15.4 per cent). The overall response rate to docetaxel and cisplatin induction chemotherapy was 65.4 per cent. A total of 23 patients (88.5 per cent) subsequently received chemoradiotherapy with a median radiotherapy dose of 70 Gy. The response rate to chemoradiotherapy was 73 per cent. At a median follow up of 44 months, the 3-year progression-free survival and overall survival rates were 62 per cent and 69 per cent, respectively.

Conclusion:

Docetaxel and cisplatin induction chemotherapy is a feasible induction regimen with comparable efficacy to docetaxel, cisplatin and 5-fluorouracil induction chemotherapy.

Keywords

Induction ChemotherapyHead and Neck NeoplasmsTaxoidsNeoadjuvant Therapy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 130 , Issue 9 , September 2016 , pp. 833 - 842
Copyright
Copyright © JLO (1984) Limited 2016 

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