Hostname: page-component-8448b6f56d-qsmjn Total loading time: 0 Render date: 2024-04-18T10:23:57.262Z Has data issue: false hasContentIssue false
  • English
  • Français

The Prediction of Complicated Clostridium difficile Infections in Children

Published online by Cambridge University Press:  10 May 2016

Sarah Tschudin-Sutter ,
Pranita D. Tamma ,
Aaron M. Milstone  and
Trish M. Perl
Sarah Tschudin-Sutter*
Affiliation:
Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland
Pranita D. Tamma
Affiliation:
Department of Pediatrics, Division of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland
Aaron M. Milstone
Affiliation:
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland Department of Pediatrics, Division of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland
Trish M. Perl
Affiliation:
Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland
*
Department of Medicine, Division of Infectious Diseases, 327 A Billings Building, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287 (stschudi@jhsph.edu).
Get access Rights & Permissions [Opens in a new window]

Extract

We validated proposed definitions for severe Clostridium difficile infection (CDI) in adults for prediction of complicated CDI in children. Complicated CDI occurred in 9 of 202 cases. Definitions for severe CDI in adults showed poor measures for discrimination of complicated CDI in children, which calls into question the usefulness of such definitions in pediatric cohorts.

Infect Control Hosp Epidemiol 2014;35(7):901–903

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 35 , Issue 7 , July 2014 , pp. 901 - 903
Copyright
© 2014 by The Society for Healthcare Epidemiology of America. All rights reserved.

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Sammons, JS, Localio, R, Xiao, R, Coffin, SE, Zaoutis, T. Clostridium difficile infection is associated with increased risk of death and prolonged hospitalization in children. Clin Infect Dis 2013;57:1–8.Google Scholar
2. Tamma, PD, Sandora, TJ. Clostridium difficile infection in children: current state and unanswered questions. J Pediatr Infect Dis 2012;1:230–243.Google Scholar
3. Cohen, SH, Gerding, DN, Johnson, S, et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect Control Hosp Epidemiol 2010;31:431–455.CrossRefGoogle Scholar
4. Debast, SB, Bauer, MP, Kuijper, EJ, et al. European Society of Clinical Microbiology and Infectious Diseases: update of the treatment guidance document for Clostridium difficile infection. Clin Microbiol Infect 2014;20(suppl 2):1–26.CrossRefGoogle ScholarPubMed
5. Tschudin-Sutter, S, Tamma, PD, Naegeli, AN, Speck, KA, Milstone, AM, Perl, TM. Distinguishing community-associated from hospital-associated Clostridium difficile infections in children: implications for public health surveillance. Clin Infect Dis 2013;57:1665–1672.Google Scholar
6. Schwartz, KL, Darwish, I, Richardson, SE, Mulvey, MR, Thampi, N. Severe clinical outcome is uncommon in Clostridium difficile infection in children: a retrospective cohort study. BMC Pediatr 2014;14:28.CrossRefGoogle ScholarPubMed
7. Khanna, S, Baddour, LM, Huskins, WC, et al. The epidemiology of Clostridium difficile infection in children: a population-based study. Clin Infect Dis 2013;56:1401–1406.Google Scholar
8. Pai, S, Aliyu, SH, Enoch, DA, Karas, JA. Five years experience of Clostridium difficile infection in children at a UK tertiary hospital: proposed criteria for diagnosis and management. PLoS One 2012;7:e51728.CrossRefGoogle Scholar
9. Kim, J, Shaklee, JF, Smathers, S, et al. Risk factors and outcomes associated with severe Clostridium difficile infection in children. Pediatr Infect Dis J 2012;31:134–138.Google Scholar
10. Bauer, MP, Notermans, DW, van Benthem, BH, et al. Clostridium difficile infection in Europe: a hospital-based survey. Lancet 2011;377:63–73.Google Scholar
11. Department of Health; Health Protection Agency. Clostridium difficile: how to deal with the problem. London: Department of Health, 2008. http://www.hpa.org.uk/webc/HPAwebFile/HPAweb_C/1232006607827. Accessed May 14, 2014.Google Scholar