Hostname: page-component-8448b6f56d-wq2xx Total loading time: 0 Render date: 2024-04-15T19:51:28.968Z Has data issue: false hasContentIssue false

Active Surveillance for Carbapenem-Resistant Enterobacteriaceae Using Stool Specimens Submitted for Testing for Clostridium difficile

Published online by Cambridge University Press:  10 May 2016

David B. Banach
Affiliation:
Mount Sinai School of Medicine, New York, New York
Jeannette Francois
Affiliation:
NewYork-Presbyterian Hospital, New York, New York
Stephanie Blash
Affiliation:
Mount Sinai School of Medicine, New York, New York
Gopi Patel
Affiliation:
Mount Sinai School of Medicine, New York, New York
Stephen G. Jenkins
Affiliation:
Weill Cornell Medical College, New York, New York
Vincent LaBombardi
Affiliation:
Mount Sinai School of Medicine, New York, New York
Barry N. Kreiswirth
Affiliation:
Public Health Research Institute, International Center for Public Health, University of Medicine and Dentistry of New Jersey, Newark, New Jersey
Arjun Srinivasan
Affiliation:
Centers for Disease Control and Prevention, Atlanta, Georgia
David P. Calfee*
Affiliation:
Weill Cornell Medical College, New York, New York
*
Weill Cornell Medical College, 525 East 68th Street, Box 265, New York, NY 10065 (dpc9003@med.cornell.edu)

Abstract

Active surveillance to identify asymptomatic carriers of carbapenem-resistant Enterobacteriaceae (CRE) is a recommended strategy for CRE control in healthcare facilities. Active surveillance using stool specimens tested for Clostridium difficile is a relatively low-cost strategy to detect CRE carriers. Further evaluation of this and other risk factor-based active surveillance strategies is warranted.

Type
Concise Communication
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2014

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

a.

Present affiliation: Yale School of Medicine, New Haven, Connecticut

b.

Present affiliation: New York Hospital Queens, Flushing, New York

References

1. Ben-David, Maor, Y, Keller, N, et al. Potential role of active surveillance in the control of a hospital-wide outbreak of carbapenem-resistant Klebsiella pneumoniae infection. Infect Control Hosp Epidemiol 2010;31:620626.Google Scholar
2. Centers for Disease Control and Prevention (CDC). Guidance for Control of Carbapenem-Resistant Enterobacteriaceae (CRE):2012 CRE Toolkit. Atlanta: CDC, 2012. http://www.cdc.gov/hai/pdfs/cre/CRE-guidance-508.pdf. Accessed May 22, 2013.Google Scholar
3. Schwaber, MJ, Klarfeld-Lidji, S, Navon-Venezia, S, Schwartz, D, Leavitt, A, Carmeli, Y. Predictors of carbapenem-resistant Klebsiella pneumoniae acquisition among hospitalized adults and effect of acquisition on mortality. Antimicrob Agents Chemother 2008;52:10281033.Google Scholar
4. Ray, AJ, Hoyen, CK, Das, SM, Eckstein, EC, Donskey, CJ. Undetected vancomycin-resistant Enterococcus stool colonization in a Veterans Affairs hospital using a Clostridium difficile-focused surveillance strategy. Infect Control Hosp Epidemiol 2002;(8):474477.Google Scholar
5. Landman, D, Salvani, JK, Bratu, S, Quale, J. Evaluation of techniques for detection of carbapenem-resistant Klebsiella pneumoniae in stool surveillance cultures. J Clin Microbiol 2005;43:56395641.Google Scholar
6. Costa, D, Vinué, L, Poeta, P, et al. Prevalence of extended-spectrum beta-lactamase-producing Escherichia colt isolates in faecal samples of broilers. Vet Microbiol 2009;138:339344.Google Scholar
7. Poirel, L, Walsh, TR, Cuvillier, V, et al. Multiplex PCR for detection of acquired carbapenemase genes. Diagn Microbiol Infect Dis 2011;70:119123.Google Scholar
8. Kaczmarek, FM, Dib-Hajj, F, Shang, W, et al. High-level carba-penem resistance in a Klebsiella pneumoniae clinical isolate is due to the combination of bla(ACT-1) beta-lactamase production, porin OmpK35/36 insertional inactivation, and down-regulation of the phosphate transport porin phoe. Antimicrob Agents Chemother 2006;50:33963406.CrossRefGoogle Scholar
9. Swaminathan, M, Sharma, S, Poliansky-Blash, S, et al. Prevalence and risk factors for acquisition of carbapenem-resistant Enterobacteriaceae in the endemic setting. Infect Control Hosp Epidemiol 2013;34(8):809817.CrossRefGoogle Scholar
10. Patel, G, Huprikar, S, Factor, SH, Jenkins, SG, Calfee, DP. Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies. Infect Control Hosp Epidemiol 2008;29:10991106.Google Scholar