Hostname: page-component-8448b6f56d-dnltx Total loading time: 0 Render date: 2024-04-23T14:38:02.313Z Has data issue: false hasContentIssue false
  • English
  • Français

Cochlear involvement in patients with ulcerative colitis

Published online by Cambridge University Press:  30 September 2015

M Sagit ,
S Guler ,
A Karaman ,
M Yasar ,
A Emiroglu  and
I Ozcan
M Sagit*
Affiliation:
Department of ENT, Kayseri Training and Research Hospital, Turkey
S Guler
Affiliation:
Department of ENT, Balıkesir Bigadic Government Hospital, Turkey
A Karaman
Affiliation:
Department of Gastroenterology, Kayseri Acıbadem Hospital, Turkey
M Yasar
Affiliation:
Department of ENT, Kayseri Training and Research Hospital, Turkey
A Emiroglu
Affiliation:
Department of ENT, Kayseri Training and Research Hospital, Turkey
I Ozcan
Affiliation:
Department of ENT, Kayseri Training and Research Hospital, Turkey
*
Address for correspondence: Dr Mustafa Sagit, Kayseri Eğitim ve Araştırma Hastanesi KBB Kliniği, Sanayi Mah. Atatürk Bulvarı Hastane Cad. No: 78, 38010, Kayseri, Turkey Fax: +90 352 320 73 13 E-mail: musagit@yahoo.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

To investigate whether cochlear involvement is an extraintestinal manifestation in patients with ulcerative colitis.

Method:

Forty-four ulcerative colitis patients and 44 age-matched healthy subjects were included in the study. Pure tone and speech audiometry, and distortion product otoacoustic emission tests were performed on all participants. The audiometric test results were compared between groups and their relationship with disease activity was investigated.

Results:

Pure tone threshold averages were significantly higher in ulcerative colitis patients compared to controls (p < 0.05). Speech discrimination scores were significantly lower in ulcerative colitis patients compared to controls (p < 0.05). Distortion product otoacoustic emission amplitude values were significantly lower for all of the tested frequencies (except for 6000 Hz in the right ear) in ulcerative colitis patients compared to controls (p < 0.05). No relationship was detected between audiometric test results and disease activity (p > 0.05).

Conclusion:

Even though hearing thresholds may be within normal limits, decreased distortion product otoacoustic emission amplitude values indicate a cochlear involvement in ulcerative colitis patients.

Keywords

Ulcerative ColitisHearing LossOtoacoustic Emissions, SpontaneousCochleaInflammatory Bowel Diseases
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 130 , Issue 2 , February 2016 , pp. 128 - 133
Copyright
Copyright © JLO (1984) Limited 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Presented at the 3rd National Otology and Neuro-otology Congress, 1–4 May 2014, Antalya, Turkey.

References

1Ordás, I, Eckmann, L, Talamini, M, Baumgart, DC, Sandborn, WJ. Ulcerative colitis. Lancet 2012;380:1606–19CrossRefGoogle ScholarPubMed
2Orchard, TR, Jewell, DP. Extraintestinal manifestations: skin, joints and mucocutaneous manifestations. In: Sartor, RB, Sandborn, W, eds. Kirshner's Inflammatory Bowel Diseases, 6th edn.Philadelphia: Saunders, 2004;658–72Google Scholar
3Rogler, G, Schölmerich, J. Extraintestinal manifestations of inflammatory bowel disease [in German]. Med Klin (Munich) 2004;99:123–30CrossRefGoogle ScholarPubMed
4Danese, S, Semeraro, S, Papa, A, Roberto, I, Scaldaferri, F, Fedeli, G et al. Extraintestinal manifestations in inflammatory bowel disease. World J Gastroenterol 2005;11:7227–36CrossRefGoogle ScholarPubMed
5Kethu, SR. Extraintestinal manifestations of inflammatory bowel diseases. J Clin Gastroenterol 2006;40:467–75CrossRefGoogle ScholarPubMed
6Podolsky, DK. Inflammatory bowel disease. N Engl J Med 1991;325:928–37CrossRefGoogle ScholarPubMed
7Billings, P. Experimental autoimmune hearing loss. J Clin Invest 2004;113:1114–17CrossRefGoogle ScholarPubMed
8Mathews, J, Kumar, B. Autoimmune sensorineural hearing loss. Clin Otolaryngol Allied Sci 2003;28:479–88CrossRefGoogle ScholarPubMed
9Kumar, B, Walsh, R, Wilson, P, Carlin, W. Sensorineural hearing loss and ulcerative colitis. J Laryngol Otol 1997;111:277–8CrossRefGoogle ScholarPubMed
10Loft, D, Dowd, A, Khan, M, Mulligan, T, Rees, W. Auditory dysfunction in inflammatory bowel disease. Eur J Gastroenterol Hepatol 1989;1:129–32Google Scholar
11Kanra, G, Kara, A, Seçmeer, G, Özen, H, Gürakan, F, Akçören, Z et al. Sensorineural hearing loss as an extra-intestinal manifestation of ulcerative colitis in an adolescent girl with pyoderma gangrenosum. Eur J Pediatr 2002;161:216–18CrossRefGoogle Scholar
12Conrad, K, Roggenbuck, D, Laass, MW. Diagnosis and classification of ulcerative colitis. Autoimmun Rev 2014;13:463–6CrossRefGoogle ScholarPubMed
13Wen, Z, Fiocchi, C. Inflammatory bowel disease: autoimmune or immune-mediated pathogenesis? Clin Dev Immunol 2004;11:195–204CrossRefGoogle ScholarPubMed
14Akbayir, N, Çalış, AB, Alkim, C, Sökmen, HM, Erdem, L, Özbal, A et al. Sensorineural hearing loss in patients with inflammatory bowel disease: a subclinical extraintestinal manifestation. Dig Dis Sci 2005;50:1938–45CrossRefGoogle ScholarPubMed
15Ott, C, Schölmerich, J. Extraintestinal manifestations and complications in IBD. Nat Rev Gastroenterol Hepatol 2013;10:585–95CrossRefGoogle ScholarPubMed
16Hoistad, DL, Schachern, PA, Paparella, MM. Autoimmune sensorineural hearing loss: a human temporal bone study. Am J Otolaryngol 1998;19:33–9CrossRefGoogle ScholarPubMed
17McCabe, BF. Autoimmune sensorineural hearing loss. Ann Otol Rhinol Laryngol 1979;88:585–9CrossRefGoogle ScholarPubMed
18Hollanders, D. Sensorineural deafness--a new complication of ulcerative colitis? Postgrad Med J 1986;62:753–5CrossRefGoogle ScholarPubMed
19Karmody, CS, Valdez, TA, Desai, U, Blevins, NH. Sensorineural hearing loss in patients with inflammatory bowel disease. Am J Otolaryngol 2009;30:166–70CrossRefGoogle ScholarPubMed
20Kalyoncu, D, Urgancı, N, Calıs, AB, Ozbal, A. Sensorineural hearing loss in pediatric patients with inflammatory bowel disease. Dig Dis Sci 2010;55:150–2CrossRefGoogle ScholarPubMed
21Kariya, S, Fukushima, K, Kataoka, Y, Tominaga, S, Nishizaki, K. Inner-ear obliteration in ulcerative colitis patients with sensorineural hearing loss. J Laryngol Otol 2008;122:871–4CrossRefGoogle ScholarPubMed
22Kimberley, BP. Applications of distortion-product emissions to an otological practice. Laryngoscope 1999;109:1908–18CrossRefGoogle Scholar