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Differences in memory function between 5-HT1A receptor genotypes in patients with major depressive disorder

Published online by Cambridge University Press:  19 January 2016

Keith A. Wesnes ,
Seth C. Hopkins ,
Helen J. Brooker  and
Kenneth S. Koblan
Keith A. Wesnes*
Affiliation:
Wesnes Cognition Ltd., Streatley on Thames, UK Department of Psychology, Northumbria University, Newcastle, UK Centre for Human Psychopharmacology, Swinburne University, Melbourne, Australia
Seth C. Hopkins
Affiliation:
Global Translational Medicine & Early Development, Sunovion Pharmaceuticals Inc., Marlborough, Massachusetts, USA
Helen J. Brooker
Affiliation:
Wesnes Cognition Ltd., Streatley on Thames, UK
Kenneth S. Koblan
Affiliation:
Global Translational Medicine & Early Development, Sunovion Pharmaceuticals Inc., Marlborough, Massachusetts, USA
*
*Address for correspondence: Professor K. A. Wesnes, Wesnes Cognition Ltd. Little Paddock, Streatley Hill, Streatley on Thames, RG8 9RD, UK. (Email: keith@wesnes.com)
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Abstract

Background

While extensive literature on the role of the serotonin receptor 1A (5-HT1A-R) in cognition exists, the findings are largely from animal studies. There has been little research conducted into 5-HT1A-R genotypes and cognitive function in humans. This article evaluates the role of 5-HT1A-R genotypes on the profile of cognitive function in patients with major depressive disorder (MDD).

Methods

The study sample was 455 MDD patients aged between 18 and 55 years. They had enrolled into a clinical trial and were tested prior to dosing on the baseline study day using the CDR System, an integrated set of 3 attention tests, 2 working memory tests, and 4 episodic memory tests. 5-HT1A-R genotyping for (SNP ID rs6295) had been conducted during the study screening period.

Results

Validated factor scores were derived from the 9 tests. It was found that patients with the C/C genotype for the C(1019)G polymorphism of the 5-HT1A-R were significantly superior in retaining and retrieving information, in both working and episodic memory, than those with either the C/G or the G/G genotypes. No differences were found in measures of attention or in the speed of retrieval of information from memory.

Conclusions

This is, to our knowledge, the first relationship found between objective tests of cognitive function and 5-HT1A-R genotypes in MDD.

Keywords

5-HT1A-Rcognitive functionCDR SystemgenotypesMDDmemory
Type
Original Research
Information
CNS Spectrums , Volume 21 , Issue 5 , October 2016 , pp. 379 - 384
Copyright
© Cambridge University Press 2016 

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