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Effects of add-on tipepidine on treatment-resistant depression: an open-label pilot trial

Published online by Cambridge University Press:  20 July 2015

Yukihiko Shirayama ,
Masatoshi Suzuki ,
Michio Takahashi ,
Koichi Sato  and
Kenji Hashimoto
Yukihiko Shirayama*
Affiliation:
Department of Psychiatry, Teikyo University Chiba Medical Center, Ichihara, Japan
Masatoshi Suzuki
Affiliation:
Department of Psychiatry, Teikyo University Chiba Medical Center, Ichihara, Japan
Michio Takahashi
Affiliation:
Department of Psychiatry, Teikyo University Chiba Medical Center, Ichihara, Japan
Koichi Sato
Affiliation:
Department of Psychiatry, Teikyo University Chiba Medical Center, Ichihara, Japan
Kenji Hashimoto
Affiliation:
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
*
Yukihiko Shirayama, Department of Psychiatry, Teikyo University Chiba Medical Center, 3426-3 Anesaki, Ichihara 299-0111, Japan. Tel: +8 143 662 1211; Fax: +8 143 662 1511; E-mail: shirayama@rapid.ocn.ne.jp
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Abstract

Objective

Treatment-resistant depression is a challenging problem in the clinical setting. Tipepidine has been used as a non-narcotic antitussive in Japan since 1959.

Methods

We administered tipepidine to 11 patients with treatment-resistant depression. Tipepidine was given for 8 weeks as an augmentation.

Results

Tipepidine significantly improved depression scores on the Hamilton Rating Scale for depression. Add-on treatment with tipepidine significantly improved scores on the trail making test and Rey auditory verbal learning test. However, no changes were observed in blood concentrations of stress-related hormones (adrenocorticotropic hormone, cortisol, dehydroepiandrosterone sulphate) with tipepidine augmentation.

Conclusion

Tipepidine might be a potential therapeutic drug for treatment-resistant depression.

Keywords

tipepidinetreatment-resistant depressionverbal learning
Type
Short Communications
Information
Acta Neuropsychiatrica , Volume 28 , Issue 1 , February 2016 , pp. 51 - 54
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Copyright
© Scandinavian College of Neuropsychopharmacology 2015 

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