Hostname: page-component-8448b6f56d-c4f8m Total loading time: 0 Render date: 2024-04-16T13:01:59.586Z Has data issue: false hasContentIssue false
  • English
  • Français

Serological divergence of Dobrava and Saaremaa hantaviruses: evidence for two distinct serotypes

Published online by Cambridge University Press:  22 March 2002

K. BRUS SJÖLANDER ,
I. GOLOVLJOVA ,
V. VASILENKO ,
A. PLYUSNIN  and
Å. LUNDKVIST
K. BRUS SJÖLANDER
Affiliation:
Swedish Institute for Infectious Disease Control, SE-171 82 Stockholm, Sweden Microbiology and Tumour Biology Centre, Karolinska Institutet, SE-171 77 Stockholm, Sweden
I. GOLOVLJOVA
Affiliation:
Institute of Experimental and Clinical Medicine, EE-11619 Tallinn, Estonia
V. VASILENKO
Affiliation:
Institute of Experimental and Clinical Medicine, EE-11619 Tallinn, Estonia
A. PLYUSNIN
Affiliation:
Swedish Institute for Infectious Disease Control, SE-171 82 Stockholm, Sweden Haartman Institute, University of Helsinki, FIN-00014 Helsinki, Finland
Å. LUNDKVIST
Affiliation:
Swedish Institute for Infectious Disease Control, SE-171 82 Stockholm, Sweden Microbiology and Tumour Biology Centre, Karolinska Institutet, SE-171 77 Stockholm, Sweden
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

In order to investigate the serological relationship of Dobrava hantavirus (DOBV, originating from Slovenia) and the Dobrava-like Saaremaa virus (SAAV, recently discovered in Estonia) we analysed 37 human serum samples, 24 from Estonia and 13 from the Balkans, by focus reduction neutralization test (FRNT). Most of the Estonian sera (19), including all sera from Saaremaa island (12), reacted with higher FRNT end-point titres to the local SAAV; the majority of them (15 and 11, respectively), with at least fourfold or higher titres to SAAV than to DOBV. In contrast, out of the 13 sera collected in Slovenia, Bosnia-Herzegovina and Greece, only one reacted more strongly with SAAV (with a twofold higher titre), while 10 of these sera reacted more strongly with the local DOBV (9/10 with fourfold or higher titres). These results indicate that DOBV and SAAV define unique hantavirus serotypes.

Type
Research Article
Information
Epidemiology & Infection , Volume 128 , Issue 1 , February 2002 , pp. 99 - 103
Copyright
2002 Cambridge University Press