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Evidence that the presence of psychosis in non-psychotic disorder is environment-dependent and mediated by severity of non-psychotic psychopathology

Published online by Cambridge University Press:  25 March 2015

S. Guloksuz ,
M. van Nierop ,
R. Lieb ,
R. van Winkel ,
H.-U. Wittchen  and
J. van Os
S. Guloksuz
Affiliation:
Department of Psychiatry and Psychology, Maastricht University Medical Centre, EURON, Maastricht, The Netherlands Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
M. van Nierop
Affiliation:
Department of Psychiatry and Psychology, Maastricht University Medical Centre, EURON, Maastricht, The Netherlands
R. Lieb
Affiliation:
Epidemiology and Health Psychology, Institute of Psychology, University of Basel, Basel, Switzerland
R. van Winkel
Affiliation:
Department of Psychiatry and Psychology, Maastricht University Medical Centre, EURON, Maastricht, The Netherlands Department of Psychiatry, University Psychiatric Center KU Leuven, KU Leuven, Belgium
H.-U. Wittchen
Affiliation:
Institute of Clinical Psychology and Psychotherapy, Technical University Dresden, Dresden, Germany Max Planck Institute of Psychiatry, Munich, Germany
J. van Os*
Affiliation:
Department of Psychiatry and Psychology, Maastricht University Medical Centre, EURON, Maastricht, The Netherlands Department of Psychosis Studies, King's College London, King's Health Partners, Institute of Psychiatry, London, UK
*
*Address for correspondence: J. van Os, Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, EURON, PO Box 616, 6200 MD Maastricht, The Netherlands. (Email: vanosj@gmail.com)
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Abstract

Background

Evidence suggests that in affective, non-psychotic disorders: (i) environmental exposures increase risk of subthreshold psychotic experiences (PEs) and strengthen connectivity between domains of affective and subthreshold psychotic psychopathology; and (ii) PEs are a marker of illness severity.

Method

In 3021 adolescents from the Early Developmental Stages of Psychopathology cohort, we tested whether the association between PEs and presence of DSM-IV mood disorder (MD)/obsessive–compulsive disorder (OCD) would be moderated by risk factors for psychosis (cannabis use, childhood trauma and urbanicity), using the interaction contrast ratio (ICR) method. Furthermore, we analysed whether the interaction between environment and PEs was mediated by non-psychotic psychopathology.

Results

The association between PEs and MD/OCD was moderated by urbanicity (ICR = 2.46, p = 0.005), cannabis use (ICR = 3.76, p = 0.010) and, suggestively, trauma (ICR = 1.91, p = 0.063). Exposure to more than one environmental risk factor increased the likelihood of co-expression of PEs in a dose–response fashion. Moderating effects of environmental exposures were largely mediated by the severity of general non-psychotic psychopathology (percentage explained 56–68%, all p < 0.001). Within individuals with MD/OCD, the association between PEs and help-seeking behaviour, as an index of severity, was moderated by trauma (ICR = 1.87, p = 0.009) and urbanicity (ICR = 1.48, p = 0.005), but not by cannabis use.

Conclusions

In non-psychotic disorder, environmental factors increase the likelihood of psychosis admixture and help-seeking behaviour through an increase in general psychopathology. The findings are compatible with a relational model of psychopathology in which more severe clinical states are the result of environment-induced disturbances spreading through a psychopathology network.

Keywords

Affective disorderscannabischildhood traumapsychosisrisk factorsurbanicity
Type
Original Articles
Information
Psychological Medicine , Volume 45 , Issue 11 , August 2015 , pp. 2389 - 2401
Copyright
Copyright © Cambridge University Press 2015 

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References

Aas, M, Etain, B, Bellivier, F, Henry, C, Lagerberg, T, Ringen, A, Agartz, I, Gard, S, Kahn, JP, Leboyer, M, Andreassen, OA, Melle, I (2014). Additive effects of childhood abuse and cannabis abuse on clinical expressions of bipolar disorders. Psychological Medicine 44, 1653–1662.CrossRefGoogle ScholarPubMed
APA (2013). Diagnostic and Statistical Manual of Mental Disorders, 5th edn. American Psychiatric Publishing: Arlington, VA.Google Scholar
Armando, M, Lin, A, Girardi, P, Righetti, V, Dario, C, Saba, R, Decrescenzo, F, Mazzone, L, Vicari, S, Birchwood, M, Fiori Nastro, P (2013). Prevalence of psychotic-like experiences in young adults with social anxiety disorder and correlation with affective dysregulation. Journal of Nervous and Mental Disease 201, 1053–1059.CrossRefGoogle ScholarPubMed
Baliki, MN, Petre, B, Torbey, S, Herrmann, KM, Huang, L, Schnitzer, TJ, Fields, HL, Apkarian, AV (2012). Corticostriatal functional connectivity predicts transition to chronic back pain. Nature Neuroscience 15, 1117–1119.Google Scholar
Bentall, RP, Wickham, S, Shevlin, M, Varese, F (2012). Do specific early-life adversities lead to specific symptoms of psychosis? A study from the 2007 Adult Psychiatric Morbidity Survey. Schizophrenia Bulletin 38, 734–740.CrossRefGoogle ScholarPubMed
Borsboom, D, Cramer, AO (2013). Network analysis: an integrative approach to the structure of psychopathology. Annual Review of Clinical Psychology 9, 91–121.Google Scholar
Bovasso, GB (2001). Cannabis abuse as a risk factor for depressive symptoms. American Journal of Psychiatry 158, 2033–2037.Google Scholar
Breetvelt, EJ, Boks, MP, Numans, ME, Selten, JP, Sommer, IE, Grobbee, DE, Kahn, RS, Geerlings, MI (2010). Schizophrenia risk factors constitute general risk factors for psychiatric symptoms in the population. Schizophrenia Research 120, 184–190.Google Scholar
Cougnard, A, Marcelis, M, Myin-Germeys, I, De Graaf, R, Vollebergh, W, Krabbendam, L, Lieb, R, Wittchen, HU, Henquet, C, Spauwen, J, Van Os, J (2007). Does normal developmental expression of psychosis combine with environmental risk to cause persistence of psychosis? A psychosis proneness–persistence model. Psychological Medicine 37, 513–527.CrossRefGoogle ScholarPubMed
Craddock, N, Owen, MJ (2010). The Kraepelinian dichotomy – going, going … but still not gone. British Journal of Psychiatry 196, 92–95.CrossRefGoogle Scholar
Cross-Disorder Group of the Psychiatric Genomics Consortium (2013). Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 381, 1371–1379.CrossRefGoogle Scholar
Darroch, J (1997). Biologic synergism and parallelism. American Journal of Epidemiology 145, 661–668.Google Scholar
Derogatis, LR, Cleary, PA (1977). Confirmation of the dimensional structure of the SCL-90: a study in construct validation. Journal of Clinical Psychology 33, 981–989.Google Scholar
DeVylder, JE, Burnette, D, Yang, LH (2014). Co-occurrence of psychotic experiences and common mental health conditions across four racially and ethnically diverse population samples. Psychological Medicine 44, 3503–3513.Google Scholar
Dominguez, MD, Saka, MC, Lieb, R, Wittchen, HU, van Os, J (2010). Early expression of negative/disorganized symptoms predicting psychotic experiences and subsequent clinical psychosis: a 10-year study. American Journal of Psychiatry 167, 1075–1082.CrossRefGoogle Scholar
Dominguez, MD, Wichers, M, Lieb, R, Wittchen, HU, van Os, J (2011). Evidence that onset of clinical psychosis is an outcome of progressively more persistent subclinical psychotic experiences: an 8-year cohort study. Schizophrenia Bulletin 37, 84–93.CrossRefGoogle ScholarPubMed
Fisher, HL, Jones, PB, Fearon, P, Craig, TK, Dazzan, P, Morgan, K, Hutchinson, G, Doody, GA, McGuffin, P, Leff, J, Murray, RM, Morgan, C (2010). The varying impact of type, timing and frequency of exposure to childhood adversity on its association with adult psychotic disorder. Psychological Medicine 40, 1967–1978.Google Scholar
Freeman, D, Dunn, G, Fowler, D, Bebbington, P, Kuipers, E, Emsley, R, Jolley, S, Garety, P (2013 a). Current paranoid thinking in patients with delusions: the presence of cognitive–affective biases. Schizophrenia Bulletin 39, 1281–1287.Google Scholar
Freeman, D, Fowler, D (2009). Routes to psychotic symptoms: trauma, anxiety and psychosis-like experiences. Psychiatry Research 169, 107–112.CrossRefGoogle ScholarPubMed
Freeman, D, Startup, H, Dunn, G, Cernis, E, Wingham, G, Pugh, K, Cordwell, J, Kingdon, D (2013 b). The interaction of affective with psychotic processes: a test of the effects of worrying on working memory, jumping to conclusions, and anomalies of experience in patients with persecutory delusions. Journal of Psychiatric Research 47, 1837–1842.Google Scholar
Fusar-Poli, P, Nelson, B, Valmaggia, L, Yung, AR, McGuire, PK (2014). Comorbid depressive and anxiety disorders in 509 individuals with an at-risk mental state: impact on psychopathology and transition to psychosis. Schizophrenia Bulletin 40, 120–131.Google Scholar
Gracie, A, Freeman, D, Green, S, Garety, PA, Kuipers, E, Hardy, A, Ray, K, Dunn, G, Bebbington, P, Fowler, D (2007). The association between traumatic experience, paranoia and hallucinations: a test of the predictions of psychological models. Acta Psychiatrica Scandinavica 116, 280–289.Google Scholar
Hammersley, P, Dias, A, Todd, G, Bowen-Jones, K, Reilly, B, Bentall, RP (2003). Childhood trauma and hallucinations in bipolar affective disorder: preliminary investigation. British Journal of Psychiatry 182, 543–547.CrossRefGoogle ScholarPubMed
Hanssen, M, Peeters, F, Krabbendam, L, Radstake, S, Verdoux, H, van Os, J (2003). How psychotic are individuals with non-psychotic disorders? Social Psychiatry and Psychiatric Epidemiology 38, 149–154.Google Scholar
Harley, M, Kelleher, I, Clarke, M, Lynch, F, Arseneault, L, Connor, D, Fitzpatrick, C, Cannon, M (2010). Cannabis use and childhood trauma interact additively to increase the risk of psychotic symptoms in adolescence. Psychological Medicine 40, 1627–1634.Google Scholar
Hartley, S, Barrowclough, C, Haddock, G (2013). Anxiety and depression in psychosis: a systematic review of associations with positive psychotic symptoms. Acta Psychiatrica Scandinavica 128, 327–346.Google Scholar
Heins, M, Simons, C, Lataster, T, Pfeifer, S, Versmissen, D, Lardinois, M, Marcelis, M, Delespaul, P, Krabbendam, L, van Os, J, Myin-Germeys, I (2011). Childhood trauma and psychosis: a case–control and case–sibling comparison across different levels of genetic liability, psychopathology, and type of trauma. American Journal of Psychiatry 168, 1286–1294.Google Scholar
Henquet, C, Krabbendam, L, Spauwen, J, Kaplan, C, Lieb, R, Wittchen, HU, van Os, J (2005). Prospective cohort study of cannabis use, predisposition for psychosis, and psychotic symptoms in young people. BMJ 330, 11.CrossRefGoogle ScholarPubMed
Houston, JE, Murphy, J, Adamson, G, Stringer, M, Shevlin, M (2008). Childhood sexual abuse, early cannabis use, and psychosis: testing an interaction model based on the National Comorbidity Survey. Schizophrenia Bulletin 34, 580–585.Google Scholar
Hovens, JG, Giltay, EJ, Wiersma, JE, Spinhoven, P, Penninx, BW, Zitman, FG (2012). Impact of childhood life events and trauma on the course of depressive and anxiety disorders. Acta Psychiatrica Scandinavica 126, 198–207.Google Scholar
Hovens, JG, Wiersma, JE, Giltay, EJ, van Oppen, P, Spinhoven, P, Penninx, BW, Zitman, FG (2010). Childhood life events and childhood trauma in adult patients with depressive, anxiety and comorbid disorders vs. controls. Acta Psychiatrica Scandinavica 122, 66–74.CrossRefGoogle ScholarPubMed
Karlson, KB, Holm, A (2011). Decomposing primary and secondary effects: a new decomposition method. Research in Social Stratification and Mobility 29, 221–237.CrossRefGoogle Scholar
Kaymaz, N, Drukker, M, Lieb, R, Wittchen, HU, Werbeloff, N, Weiser, M, Lataster, T, van Os, J (2012). Do subthreshold psychotic experiences predict clinical outcomes in unselected non-help-seeking population-based samples? A systematic review and meta-analysis, enriched with new results. Psychological Medicine 42, 2239–2253.Google Scholar
Kaymaz, N, Krabbendam, L, de Graaf, R, Nolen, W, Ten Have, M, van Os, J (2006). Evidence that the urban environment specifically impacts on the psychotic but not the affective dimension of bipolar disorder. Social Psychiatry and Psychiatric Epidemiology 41, 679–685.CrossRefGoogle Scholar
Kaymaz, N, van Os, J, de Graaf, R, Ten Have, M, Nolen, W, Krabbendam, L (2007). The impact of subclinical psychosis on the transition from subclinicial mania to bipolar disorder. Journal of Affective Disorders 98, 55–64.CrossRefGoogle ScholarPubMed
Kedzior, KK, Laeber, LT (2014). A positive association between anxiety disorders and cannabis use or cannabis use disorders in the general population – a meta-analysis of 31 studies. BMC Psychiatry 14, 136.Google Scholar
Kelleher, I, Keeley, H, Corcoran, P, Lynch, F, Fitzpatrick, C, Devlin, N, Molloy, C, Roddy, S, Clarke, MC, Harley, M, Arseneault, L, Wasserman, C, Carli, V, Sarchiapone, M, Hoven, C, Wasserman, D, Cannon, M (2012 a). Clinicopathological significance of psychotic experiences in non-psychotic young people: evidence from four population-based studies. British Journal of Psychiatry 201, 26–32.Google Scholar
Kelleher, I, Murtagh, A, Molloy, C, Roddy, S, Clarke, MC, Harley, M, Cannon, M (2012 b). Identification and characterization of prodromal risk syndromes in young adolescents in the community: a population-based clinical interview study. Schizophrenia Bulletin 38, 239–246.CrossRefGoogle ScholarPubMed
Kendler, KS, Gardner, CO (2010). Interpretation of interactions: guide for the perplexed. British Journal of Psychiatry 197, 170–171.CrossRefGoogle ScholarPubMed
Knol, MJ, van der Tweel, I, Grobbee, DE, Numans, ME, Geerlings, MI (2007). Estimating interaction on an additive scale between continuous determinants in a logistic regression model. International Journal of Epidemiology 36, 1111–1118.Google Scholar
Kohler, U, Karlson, KB, Holm, A (2011). Comparing coefficients of nested nonlinear probability models. Stata Journal 11, 420–438.CrossRefGoogle Scholar
Konings, M, Stefanis, N, Kuepper, R, de Graaf, R, ten Have, M, van Os, J, Bakoula, C, Henquet, C (2012). Replication in two independent population-based samples that childhood maltreatment and cannabis use synergistically impact on psychosis risk. Psychological Medicine 42, 149–159.Google Scholar
Kuepper, R, Henquet, C, Lieb, R, Wittchen, HU, van Os, J (2011 a). Non-replication of interaction between cannabis use and trauma in predicting psychosis. Schizophrenia Research 131, 262–263.Google Scholar
Kuepper, R, van Os, J, Lieb, R, Wittchen, HU, Henquet, C (2011 b). Do cannabis and urbanicity co-participate in causing psychosis? Evidence from a 10-year follow-up cohort study. Psychological Medicine 41, 2121–2129.Google Scholar
Kuepper, R, van Os, J, Lieb, R, Wittchen, HU, Hofler, M, Henquet, C (2011 c). Continued cannabis use and risk of incidence and persistence of psychotic symptoms: 10 year follow-up cohort study. BMJ 342, d738.Google Scholar
Leverich, GS, McElroy, SL, Suppes, T, Keck, PE Jr, Denicoff, KD, Nolen, WA, Altshuler, LL, Rush, AJ, Kupka, R, Frye, MA, Autio, KA, Post, RM (2002). Early physical and sexual abuse associated with an adverse course of bipolar illness. Biological Psychiatry 51, 288–297.CrossRefGoogle ScholarPubMed
Lieb, R, Isensee, B, von Sydow, K, Wittchen, HU (2000). The Early Developmental Stages of Psychopathology Study (EDSP): a methodological update. European Addiction Research 6, 170–182.Google Scholar
Linscott, RJ, van Os, J (2013). An updated and conservative systematic review and meta-analysis of epidemiological evidence on psychotic experiences in children and adults: on the pathway from proneness to persistence to dimensional expression across mental disorders. Psychological Medicine 43, 1133–1149.CrossRefGoogle ScholarPubMed
Manrique-Garcia, E, Zammit, S, Dalman, C, Hemmingsson, T, Andreasson, S, Allebeck, P (2012). Cannabis, schizophrenia and other non-affective psychoses: 35 years of follow-up of a population-based cohort. Psychological Medicine 42, 1321–1328.CrossRefGoogle ScholarPubMed
Minozzi, S, Davoli, M, Bargagli, AM, Amato, L, Vecchi, S, Perucci, CA (2010). An overview of systematic reviews on cannabis and psychosis: discussing apparently conflicting results. Drug Alcohol Review 29, 304–317.Google Scholar
Moore, THM, Zammit, S, Lingford-Hughes, A, Barnes, TRE, Jones, PB, Burke, M, Lewis, G (2007). Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review. Lancet 370, 319–328.CrossRefGoogle ScholarPubMed
Morgan, C, Reininghaus, U, Reichenberg, A, Frissa, S, SELCoH study team, Hotopf, M, Hatch, SL (2014). Adversity, cannabis use and psychotic experiences: evidence of cumulative and synergistic effects. British Journal of Psychiatry 204, 346–353.Google Scholar
Nanni, V, Uher, R, Danese, A (2012). Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression: a meta-analysis. American Journal of Psychiatry 169, 141–151.Google Scholar
Perlis, RH, Uher, R, Ostacher, M, Goldberg, JF, Trivedi, MH, Rush, AJ, Fava, M (2011). Association between bipolar spectrum features and treatment outcomes in outpatients with major depressive disorder. Archives of General Psychiatry 68, 351–360.CrossRefGoogle ScholarPubMed
Read, J, van Os, J, Morrison, AP, Ross, CA (2005). Childhood trauma, psychosis and schizophrenia: a literature review with theoretical and clinical implications. Acta Psychiatrica Scandinavica 112, 330–350.Google Scholar
Reed, V, Gander, F, Pfister, H, Steiger, A, Sonntag, H, Trenkwalder, C, Hundt, W, Wittchen, H-U (1998). To what degree does the Composite International Diagnostic Interview (CIDI) correctly identify DSM-IV disorders? Testing validity issues in a clinical sample. International Journal of Methods in Psychiatric Research 7, 142–155.Google Scholar
Reeves, LE, Anglin, DM, Heimberg, RG, Gibson, LE, Fineberg, AM, Maxwell, SD, Kerns, CM, Ellman, LM (2014). Anxiety mediates the association between cannabis use and attenuated positive psychotic symptoms. Psychiatry Research 218, 180–186.Google Scholar
Rietdijk, J, Hogerzeil, SJ, van Hemert, AM, Cuijpers, P, Linszen, DH, van der Gaag, M (2011). Pathways to psychosis: help-seeking behavior in the prodromal phase. Schizophrenia Research 132, 213–219.Google Scholar
Rossler, W, Hengartner, MP, Ajdacic-Gross, V, Haker, H, Gamma, A, Angst, J (2011). Sub-clinical psychosis symptoms in young adults are risk factors for subsequent common mental disorders. Schizophrenia Research 131, 18–23.CrossRefGoogle ScholarPubMed
Rothman, KJ, Greenland, S, Walker, AM (1980). Concepts of interaction. American Journal of Epidemiology 112, 467–470.CrossRefGoogle ScholarPubMed
Schwartz, S, Susser, E (2006). Relationships among causes. In Psychiatric Epidemiology: Searching for the Causes of Mental Disorders (ed. Susser, E., Schwartz, S., Morabia, A. and Bromet, E.). Oxford and New York: Oxford University Press.Google Scholar
Smeets, F, Lataster, T, Dominguez, MD, Hommes, J, Lieb, R, Wittchen, HU, van Os, J (2012). Evidence that onset of psychosis in the population reflects early hallucinatory experiences that through environmental risks and affective dysregulation become complicated by delusions. Schizophrenia Bulletin 38, 531–542.Google Scholar
Smeets, F, Lataster, T, Viechtbauer, W, Delespaul, P, G.R.O.U.P. (2014). Evidence that environmental and genetic risks for psychotic disorder may operate by impacting on connections between core symptoms of perceptual alteration and delusional ideation. Schizophrenia Bulletin. Published online 12 09 2014 . doi:10.1093/schbul/sbu122.Google Scholar
Spauwen, J, Krabbendam, L, Lieb, R, Wittchen, HU, van Os, J (2004). Does urbanicity shift the population expression of psychosis? Journal of Psychiatric Research 38, 613–618.Google Scholar
Spauwen, J, Krabbendam, L, Lieb, R, Wittchen, HU, van Os, J (2006). Impact of psychological trauma on the development of psychotic symptoms: relationship with psychosis proneness. British Journal of Psychiatry 188, 527–533.Google Scholar
StataCorp (2013). Stata/SE Statistical Software, Release 13.1. StataCorp LP: College Station, TX.Google Scholar
Sundquist, K, Frank, G, Sundquist, J (2004). Urbanisation and incidence of psychosis and depression: follow-up study of 4.4 million women and men in Sweden. British Journal of Psychiatry 184, 293–298.CrossRefGoogle ScholarPubMed
Treserras, S, Boulanouar, K, Conchou, F, Simonetta-Moreau, M, Berry, I, Celsis, P, Chollet, F, Loubinoux, I (2009). Transition from rest to movement: brain correlates revealed by functional connectivity. NeuroImage 48, 207–216.Google Scholar
van Dam, DS, van Nierop, M, Viechtbauer, W, Velthorst, E, van Winkel, R, Genetic, Risk and Outcome of Psychosis (GROUP) investigators, Bruggeman, R, Cahn, W, de Haan, L, Kahn, RS, Meijer, CJ, Myin-Germeys, I, van Os, J, Wiersma, D (2014). Childhood abuse and neglect in relation to the presence and persistence of psychotic and depressive symptomatology. Psychological Medicine. Published online 17 07 2014 . doi:10.1017/S0033291714001561.Google Scholar
Van Nierop, M, Viechtbauer, W, Gunther, N, van Zelst, C, de Graaf, R, ten Have, M, van Dorsselaer, S, Bak, M, G.R.O.U.P. Investigators, van Winkel R (in press). Childhood trauma is associated with a specific admixture of affective, anxiety, and psychotic symptoms cutting across traditional diagnostic boundaries. Psychological Medicine.Google Scholar
van Os, J (2013). The dynamics of subthreshold psychopathology: implications for diagnosis and treatment. American Journal of Psychiatry 170, 695–698.Google Scholar
van Os, J, Kenis, G, Rutten, BP (2010). The environment and schizophrenia. Nature 468, 203–212.CrossRefGoogle ScholarPubMed
van Os, J, Lataster, T, Delespaul, P, Wichers, M, Myin-Germeys, I (2014). Evidence that a psychopathology interactome has diagnostic value, predicting clinical needs: an experience sampling study. PLOS ONE 9, e86652.Google Scholar
van Rossum, I, Dominguez, MD, Lieb, R, Wittchen, HU, van Os, J (2011). Affective dysregulation and reality distortion: a 10-year prospective study of their association and clinical relevance. Schizophrenia Bulletin 37, 561–571.Google Scholar
van Winkel, R, Kuepper, R (2014). Epidemiological, neurobiological, and genetic clues to the mechanisms linking cannabis use to risk for nonaffective psychosis. Annual Review of Clinical Psychology 10, 767–791.Google Scholar
van Winkel, R, van Nierop, M, Myin-Germeys, I, van Os, J (2013). Childhood trauma as a cause of psychosis: linking genes, psychology, and biology. Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie 58, 44–51.Google Scholar
Varese, F, Smeets, F, Drukker, M, Lieverse, R, Lataster, T, Viechtbauer, W, Read, J, van Os, J, Bentall, RP (2012). Childhood adversities increase the risk of psychosis: a meta-analysis of patient–control, prospective- and cross-sectional cohort studies. Schizophrenia Bulletin 38, 661–671.Google Scholar
Varghese, D, Scott, J, Welham, J, Bor, W, Najman, J, O'Callaghan, M, Williams, G, McGrath, J (2011). Psychotic-like experiences in major depression and anxiety disorders: a population-based survey in young adults. Schizophrenia Bulletin 37, 389–393.Google Scholar
Varotto, G, Visani, E, Canafoglia, L, Franceschetti, S, Avanzini, G, Panzica, F (2012). Enhanced frontocentral EEG connectivity in photosensitive generalized epilepsies: a partial directed coherence study. Epilepsia 53, 359–367.Google Scholar
Vassos, E, Pedersen, CB, Murray, RM, Collier, DA, Lewis, CM (2012). Meta-analysis of the association of urbanicity with schizophrenia. Schizophrenia Bulletin 38, 1118–1123.CrossRefGoogle ScholarPubMed
Wigman, JT, van Nierop, M, Vollebergh, WA, Lieb, R, Beesdo-Baum, K, Wittchen, HU, van Os, J (2012). Evidence that psychotic symptoms are prevalent in disorders of anxiety and depression, impacting on illness onset, risk, and severity – implications for diagnosis and ultra-high risk research. Schizophrenia Bulletin 38, 247–257.Google Scholar
Wigman, JT, van Os, J, Thiery, E, Derom, C, Collip, D, Jacobs, N, Wichers, M (2013). Psychiatric diagnosis revisited: towards a system of staging and profiling combining nomothetic and idiographic parameters of momentary mental States. PLOS ONE 8, e59559.Google Scholar
Wigman, JT, van Winkel, R, Raaijmakers, QA, Ormel, J, Verhulst, FC, Reijneveld, SA, van Os, J, Vollebergh, WA (2011 a). Evidence for a persistent, environment-dependent and deteriorating subtype of subclinical psychotic experiences: a 6-year longitudinal general population study. Psychological Medicine 41, 2317–2329.Google Scholar
Wigman, JT, Vollebergh, WA, Raaijmakers, QA, Iedema, J, van Dorsselaer, S, Ormel, J, Verhulst, FC, van Os, J (2011 b). The structure of the extended psychosis phenotype in early adolescence – a cross-sample replication. Schizophrenia Bulletin 37, 850–860.Google Scholar
Wittchen, HU, Lachner, G, Wunderlich, U, Pfister, H (1998 a). Test–retest reliability of the computerized DSM-IV version of the Munich-Composite International Diagnostic Interview (M-CIDI). Social Psychiatry and Psychiatric Epidemiology 33, 568–578.Google Scholar
Wittchen, HU, Perkonigg, A, Lachner, G, Nelson, CB (1998 b). Early Developmental Stages of Psychopathology Study (EDSP): objectives and design. European Addiction Research 4, 18–27.CrossRefGoogle ScholarPubMed
Wittchen, HU, Pfister, H (1997). DIA-X-Interviews: Manual fur Screening-Verfahren und Interview; Interviewheft Langsschnittuntersuchung (DIA-X-Lifetime); Enganzungsheft (DIA-X-Lifetime); Interviewheft Querschnittsuntersuchung (DIA-X-Monatsversion); Erganzungsheft (DIA-X-12 Monatsversion); PC-Programm zur Durchfuhrung der Interviews (Langsund Querschnittsuntersuchung). Ausertungsprogramm. Swets & Zeiltinger: Frankfurt, Germany.Google Scholar
Zimmermann, P, Bruckl, T, Lieb, R, Nocon, A, Ising, M, Beesdo, K, Wittchen, HU (2008). The interplay of familial depression liability and adverse events in predicting the first onset of depression during a 10-year follow-up. Biological Psychiatry 63, 406–414.CrossRefGoogle Scholar