Epidemiology and Infection

Short Report

Bacterial and other infections

Surveillance of antibiotic susceptibility of Enterobacteriaceae isolated from urine samples collected from community patients in a large metropolitan area, 2010–2012

C. S. HORNERa1a2 c1, N. ABBERLEYa1, M. DENTONa1a2 and M. H. WILCOXa1a2

a1 Leeds Teaching Hospitals NHS Trust, Department of Microbiology, Old Medical School, Leeds General Infirmary, Leeds, UK

a2 Health Protection Agency, Leeds, UK

SUMMARY

Antibiotic susceptibilities of large cohorts of Enterobacteriaceae isolated from urine collected in the community are scarce. We report the susceptibilities of Enterobacteriaceae isolated from urine of non-selected community populations in a metropolitan area (Leeds and Bradford, UK) over 2 years. Isolates (n = 6614) were identified as follows: Escherichia coli (n = 5436), Klebsiella spp. (n = 525), Proteus mirabilis (n = 305), and 15 other species (n = 290); 58 isolates were unidentified. Ampicillin resistance was observed in 53% E. coli and 28% P. mirabilis; ≥34% E. coli and P. mirabilis were non-susceptible to trimethoprim compared to 20% Klebsiella spp.; nitrofurantoin resistance was observed in 3% E. coli and 15% Klebsiella spp. The occurrence of extended-spectrum β-lactamases (ESBL) was low (6%), as was non-susceptibility to carbapenems, cefipime and tigecycline (<2%). Further surveillance is required to monitor this level of resistance and additional clinical studies are needed to understand the impact on the outcome of current empirical prescribing decisions.

(Received December 13 2012)

(Revised April 04 2013)

(Accepted April 04 2013)

(Online publication May 09 2013)

Key words

  • Antibiotic resistance;
  • Enterobacteriaceae;
  • surveillance;
  • urinary tract infections (UTIs)

Correspondence

c1 Author for correspondence: Dr C. S. Horner, Leeds Teaching Hospitals NHS Trust, Department of Microbiology, Old Medical School, Leeds General Infirmary, Leeds, UK. (Email: carolyne.horner@leedsth.nhs.uk)

Footnotes

  This work was presented at the Health Protection Agency Conference, Warwick 2012, poster number P104.

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