Epidemiology and Infection

Original Papers

Gastroenteritis

Burden of illness and factors associated with duration of illness in clinical campylobacteriosis

A. E. DECKERTa1a2 c1, R. J. REID-SMITHa1a2, S. TAMBLYNa3, L. MORRELLa4, P. SELISKEa5, F. B. JAMIESONa6, R. IRWINa2, C. E. DEWEYa1, P. BOERLINa7 and S. A. McEWENa1

a1 Population Medicine, University of Guelph, Guelph, Ontario, Canada

a2 Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, Guelph, Ontario, Canada

a3 Public Health Consultant, Stratford, Ontario, Canada

a4 Perth District Health Unit, Stratford, Ontario, Canada

a5 Wellington-Dufferin-Guelph District Health Unit, Guelph, Ontario, Canada

a6 Public Health Ontario, Toronto, Ontario, Canada

a7 Pathobiology, University of Guelph, Guelph, Ontario, Canada

SUMMARY

A population-based study investigated the burden of illness, including the duration of illness associated with laboratory-confirmed cases of campylobacteriosis in two health unit areas. Questionnaire data were collected for 250 cases. The median duration of illness was 8 days and 66% of cases reported symptoms of moderate severity or greater. A Cox proportional hazards model identified antimicrobial use factors associated with a significantly increased rate of symptom resolution (shorter duration of illness): macrolides for less than the recommended number of days, ciprofloxacin for at least 3 days, and antimicrobials not recommended for campylobacteriosis. The impact of antimicrobial use was consistent regardless of when, during the course of illness, the antimicrobial use began. The effectiveness of ciprofloxacin in these results may be due to the low prevalence of resistance to ciprofloxacin in isolates from this study. The effect of antimicrobials not recommended for campylobacteriosis should be further investigated.

(Received May 22 2012)

(Revised January 23 2013)

(Accepted January 27 2013)

(Online publication March 08 2013)

Key words

  • Antimicrobial drugs;
  • Campylobacter ;
  • epidemiology;
  • modelling

Correspondence

c1 Author for correspondence: A. E. Deckert, 160 Research Lane, Suite 103, Guelph, Ontario, Canada N1 G 5B2. (Email: adeckert@uoguelph.ca)

Metrics