Epidemiology and Infection

Original Papers

MRSA and HAI

Prevalence, risk factors and molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) colonization in residents of long-term care facilities in Luxembourg, 2010

J. MOSSONGa1 c1, E. GELHAUSENa2, F. DECRUYENAEREa3, A. DEVAUXa1, M. PERRINa3, J. EVENa4 and E. HEISBOURGa2

a1 Surveillance & Epidemiology of Infectious Diseases, National Health Laboratory, Luxembourg

a2 Curative Medicine, Health Directorate, Luxembourg

a3 Bacteriology, National Health Laboratory, Luxembourg

a4 Serology & Virology, National Health Laboratory, Luxembourg

SUMMARY

A prevalence survey of methicillin-resistant Staphylococcus aureus (MRSA) was performed in 2010 in 19 long-term care facilities in Luxembourg. Of the 954 participating residents, 69 (7·2%) were colonized by MRSA. Previous history of MRSA [odds ratio (OR) 7·20, 95% confidence interval (CI) 3·19–16·27], quinolone therapy in the previous year (OR 2·27, 95% CI 1·17–4·41) and ≥24 h care administered per week (OR 4·29, 95% CI 1·18–15·56) were independent risk factors for MRSA colonization. More than 75% of strains were of clonal complex (CC)5, mainly spa-type t003 or sequence type (ST)225 and ST710, which is a rapidly emerging lineage prevalent in central Europe. Five residents were colonized by livestock-associated genotypes belonging to CC398. Previously dominant CC8 strains have recently been replaced by more resistant CC5 strains in Luxembourg.

(Received May 21 2012)

(Revised August 09 2012)

(Accepted August 09 2012)

(Online publication September 07 2012)

Key words

  • Antibiotic resistance;
  • antimicrobial resistance in agricultural settings;
  • hospital-acquired (nosocomial) infections;
  • methicillin-resistant S. aureus (MRSA);
  • molecular epidemiology

Correspondence

c1 Author for correspondence: Dr J. Mossong, Surveillance & Epidemiology of Infectious Diseases, National Health Laboratory, 42 rue du Laboratoire, L-1911 Luxembourg, Luxembourg. (Email: joelmossong@gmail.com)

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