Journal of Developmental Origins of Health and Disease

Original Article

Lingering prenatal effects of the 1918 influenza pandemic on cardiovascular disease

B. Mazumdera1, D. Almonda2, K. Parka3, E. M. Crimminsa4 and C. E. Fincha4 c1

a1 Federal Reserve Bank of Chicago, Chicago, IL, USA

a2 Department of Economics and SIPA, Columbia University, New York, NY, USA

a3 Harris School of Public Policy, University of Chicago, Chicago, IL, USA

a4 Andrus Gerontology Center, University of Southern California, Los Angeles, CA, USA


Prenatal exposure to the 1918 influenza pandemic (Influenza A, H1N1 subtype) is associated with ≥20% excess cardiovascular disease at 60 to 82 years of age, relative to cohorts born without exposure to the influenza epidemic, either prenatally or postnatally (defined by the quarter of birth), in the 1982–1996 National Health Interview Surveys of the USA. Males showed stronger effects of influenza on increased later heart disease than females. Adult height at World War II enlistment was lower for the 1919 birth cohort than for those born in adjacent years, suggesting growth retardation. Calculations on the prevalence of maternal infections indicate that prenatal exposure to even uncomplicated maternal influenza may have lasting consequences later in life. These findings suggest novel roles for maternal infections in the fetal programming of cardiovascular risk factors that are independent of maternal malnutrition.

(Online publication October 01 2009)