In recent years, the area of Product Design focusing on the Product's Life Cycle, from conception through disposal, has been an increasing area of research, in academia and industry. It provides a challenging, yet relatively unexplored, area of research for scientists and engineers from multiple disciplines. It is also an area of great interest to industry, with the refocusing of business models from increasing product performance to increasing corporate profitability while reducing expenditures. This paradigm shift has spawned multiple areas of research in Life-Cycle Design, as evidenced by the diversity in the topics of the papers submitted for this special issue of AI EDAM. We have collected five papers that present different areas of Life-Cycle Design; each provides a unique perspective on Life Cycle Design within the broad domain of Artificial Intelligence.