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Abnormal white matter integrity as a structural endophenotype for bipolar disorder

Published online by Cambridge University Press:  07 March 2016

A. Sarıçiçek ,
N. Zorlu ,
N. Yalın ,
C. Hıdıroğlu ,
B. Çavuşoğlu ,
D. Ceylan ,
E. Ada ,
Z. Tunca  and
A. Özerdem
A. Sarıçiçek*
Affiliation:
Department of Psychiatry, Faculty of Medicine, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey Department of Neuroscience, Health Sciences Institute, Dokuz Eylul University, Izmir, Turkey
N. Zorlu
Affiliation:
Department of Psychiatry, Faculty of Medicine, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey
N. Yalın
Affiliation:
Department of Neuroscience, Health Sciences Institute, Dokuz Eylul University, Izmir, Turkey Department of Psychiatry, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey
C. Hıdıroğlu
Affiliation:
Department of Neuroscience, Health Sciences Institute, Dokuz Eylul University, Izmir, Turkey
B. Çavuşoğlu
Affiliation:
Department of Neuroscience, Health Sciences Institute, Dokuz Eylul University, Izmir, Turkey
D. Ceylan
Affiliation:
Department of Neuroscience, Health Sciences Institute, Dokuz Eylul University, Izmir, Turkey Psychiatry Clinic, Gumushane State Hospital, Gumushane, Turkey
E. Ada
Affiliation:
Department of Radiology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey
Z. Tunca
Affiliation:
Department of Neuroscience, Health Sciences Institute, Dokuz Eylul University, Izmir, Turkey Department of Psychiatry, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey
A. Özerdem
Affiliation:
Department of Neuroscience, Health Sciences Institute, Dokuz Eylul University, Izmir, Turkey Department of Psychiatry, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey
*
*Address for correspondence: A. Sarıçiçek, M.D., İzmir Katip Çelebi Üniversitesi, Atatürk Eğitim ve Araştırma Hastanesi Psikiyatri Anabilim Dalı AMATEM Binası Zemin Kat, Basın Sitesi, İzmir, Turkey. (Email: aybala.saricicek@gmail.com)
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Abstract

Background

Several lines of evidence suggest that bipolar disorder (BD) is associated with white matter (WM) pathology. Investigation of unaffected first-degree relatives of BD patients may help to distinguish structural biomarkers of genetic risk without the confounding effects of burden of illness, medication or clinical state. In the present study, we applied tract-based spatial statistics to study WM changes in patients with BD, unaffected siblings and controls.

Method

A total of 27 euthymic patients with BD type I, 20 unaffected siblings of bipolar patients and 29 healthy controls who did not have any current or past diagnosis of Axis I psychiatric disorders were enrolled in the study.

Results

Fractional anisotropy (FA) was significantly lower in BD patients than in the control group in the corpus callosum, fornix, bilateral superior longitudinal fasciculus, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, anterior thalamic radiation, posterior thalamic radiation, cingulum, uncinate fasciculus, superior corona radiata, anterior corona radiata and left external capsule. In region-of-interest (ROI) analyses, we found that both unaffected siblings and bipolar patients had significantly reduced FA in the left posterior thalamic radiation, the left sagittal stratum, and the fornix compared with healthy controls. Average FA for unaffected siblings was intermediate between the healthy controls and bipolar patients within these ROIs.

Conclusions

Decreased FA in the fornix, left posterior thalamic radiation and left sagittal stratum in both bipolar patients and unaffected siblings may represent a potential structural endophenotype or a trait-based marker for BD.

Keywords

Bipolar disorderdiffusion tensor imagingendophenotypesfractional anisotropysiblingswhite matter
Type
Original Articles
Information
Psychological Medicine , Volume 46 , Issue 7 , May 2016 , pp. 1547 - 1558
Copyright
Copyright © Cambridge University Press 2016 

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