Behavioral and Brain Sciences

Open Peer Commentary
Quartz & Sejnowski: Cognitive development

Stimulus configuration, long-term potentiation, and the hippocampus

Nestor A. Schmajuk a1
a1 Department of Psychology: Experimental, Duke University, Durham, NC 27706


Shors & Matzel propose that hippocampal LTP increases the effective salience of discrete external stimuli and thereby facilitates the induction of memories at distant places. In line with this suggestion, a neural network model of associative learning and hippocampal function assumes that LTP increases hippocampal error signals to the cortex, thereby facilitating stimulus configuration in association cortex. Computer simulations show that under these assumptions the model correctly describes the effect of LTP induction and blockade in classical discriminations and place learning.