Behavioral and Brain Sciences

Open Peer Commentary

Impulsivity, dual diagnosis, and the structure of motivated behavior in addiction

R. Andrew Chambersa1

a1 Department of Psychiatry, Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, IN 46202.


Defining brain mechanisms that control and adapt motivated behavior will not only advance addiction treatment. It will help society see that addiction is a disease that erodes free will, rather than representing a free will that asks for or deserves consequences of drug-use choices. This science has important implications for understanding addiction's comorbidity in mental illness and reducing associated public health and criminal justice burdens.