Behavioral and Brain Sciences

Open Peer Commentary
Depue & Collins: Neurobiology of personality

Is depression a dysfunction in self-regulating the brain/behavior system for approach?

Timothy J. Strauman a1
a1 Department of Psychiatry, University of Wisconsin-Madison, Madison, WI 53719-1176


This commentary examines the implications of the Depue & Collins model for the etiology and treatment of depression, specifically, whether it can account for findings concerning neurobiological, behavioral, and phenomenological facets of depression. Drawing upon the construct of self-regulation, I explore the fit of the model to current knowledge about depression, conceptualized as a dysfunction within a hypothetical brain/behavior system for maximizing positive outcomes.