Behavioral and Brain Sciences

Open Peer Commentary
Quartz & Sejnowski: Cognitive development

LTP plays a distinct role in various brain structures

Ken-ichi Hara a1 and Tatsuo Kitajima a2
a1 Faculty of Science and Engineering, Ishinomaki Sensyu University, Ishinomaki, Miyagi, 986 Japan
a2 Faculty of Engineering, Yamagata University, Yonezawa, Yamagata, 992 Japan


LTP is thought to be an experimental model for studying the cellular mechanism of learning and memory. Shors & Matzel review some contradictory data concerning the linkage between LTP and memory and suggest that LTP does not underlie learning and memory. LTP is a cellular and synaptic process and cannot be a memory mechanism. In fact, it is a cellular information storage mechanism.