Behavioral and Brain Sciences

Authors' Response

An evolutionary framework for mental disorders: Integrating adaptationist and evolutionary genetic models

Matthew C. Keller a1 and Geoffrey Miller a2
a1 Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonweatlh University, Richmond, VA 23219;
a2 Department of Psychology, University of New Mexico, Albuquerque, NM 87131-1161.

Article author query
keller mc   [PubMed][Google Scholar] 
miller g   [PubMed][Google Scholar] 


This response (a) integrates non-equilibrium evolutionary genetic models, such as coevolutionary arms-races and recent selective sweeps, into a framework for understanding common, harmful, heritable mental disorders; (b) discusses the forms of ancestral neutrality or balancing selection that may explain some portion of mental disorder risk; and (c) emphasizes that normally functioning psychological adaptations work against a backdrop of mutational and environmental noise.

(Published Online November 9 2006)