Behavioral and Brain Sciences

Short Communication

The role of frontocingulate pathways in the emotion-cognition interface: Emerging clues from depression

Diego A. Pizzagalli a1
a1 Department of Psychology, Harvard University, Cambridge, MA 02138


By emphasizing nonlinear dynamics between appraisal and emotions, Lewis's model provides a valuable platform for integrating psychological and neural perspectives on the emotion-cognition interface. In this commentary, I discuss the role of neuroscience in shaping new conceptualizations of emotion and the putative role of theta oscillation within frontocingulate pathways in depression, a syndrome in which emotion-cognition relations are dysfunctional.