The International Journal of Neuropsychopharmacology

Research Article

Chronic modafinil effects on drug-seeking following methamphetamine self-administration in rats

Carmela M. Reichela1 c1 and Ronald E. Seea1

a1 Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA


Acute administration of the cognitive enhancing drug, modafinil (Provigil®), reduces methamphetamine (Meth) seeking following withdrawal from daily self-administration. However, the more clinically relevant effects of modafinil on Meth-seeking after chronic treatment have not been explored. Here, we determined the impact of modafinil on Meth-seeking after chronic daily treatment during extinction or abstinence following Meth self-administration. Rats self-administered intravenous Meth during daily 2-h sessions for 14 d, followed by extinction sessions or abstinence. During this period, rats received daily injections of vehicle, 30, or 100 mg/kg modafinil and were then tested for Meth-seeking via cue, Meth-primed, and context-induced reinstatement at early and late withdrawal time-points. We found that chronic modafinil attenuated relapse to a Meth-paired context, decreased conditioned cue-induced and Meth-primed reinstatement, and resulted in enduring reductions in Meth-seeking even after discontinuation of treatment. Additionally, we determined that only a very high dose of modafinil (300 mg/kg) during maintenance of self-administration had an impact on Meth intake. These results validate and extend clinical and preclinical findings that modafinil may be a viable treatment option for Meth addiction.

(Received March 05 2011)

(Reviewed April 16 2011)

(Revised May 05 2011)

(Accepted May 26 2011)

(Online publication June 28 2011)


c1 Address for correspondence: Dr C. M. Reichel, Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA. Tel.: 843-792-4272 Fax: 843-792-4423 Email: