Behavioral and Brain Sciences

Open Peer Commentary

Mutations, developmental instability, and the Red Queen

Steven W. Gangestad a1 and Ronald A. Yeo a1
a1 Department of Psychology, University of New Mexico, Albuquerque, NM 87111.

Article author query
gangestad sw   [PubMed][Google Scholar] 
yeo ra   [PubMed][Google Scholar] 


We address two points. First, one must explain how different, rare mutations ultimately lead to common psychopathological conditions. The developmental instability model offers one solution. Second, Keller & Miller (K&M) perhaps miss the major processes other than variation fueled by rare deleterious mutations that account for interesting genetic variation in psychopathology, particularly when single alleles have non-negligible effects: Red Queen processes.

(Published Online November 9 2006)