Behavioral and Brain Sciences

Open Peer Commentary
Quartz & Sejnowski: Cognitive development

LTP is neither a memory trace nor an ultimate mechanism for its formation: The beginning of the end of the synaptic theory of neural memory

Lev P. Latash a1
a1 Department of Psychology, Institute for the Study of Developmental Disabilities, University of Illinois at Chicago, Chicago, IL 60613


The problem of neural memory storage is discussed, based on the results of studies of memory impairment after hippocampal lesions, motor learning, and electrophysiological research on “spinal memory.” I support Shors & Matzel's major statements. The absence of reliable evidence on the LTP memory storage function and other data cast doubt on the synaptic theory of memory.