Behavioral and Brain Sciences

Continuing Commentary
Tracey J. Shors & Louis D. Matzel (1997) Long-term potentiation: What's learning got to do with it? BBS 20:597–655

LTP and reinforcement: Possible role of the monoaminergic systems

Mikhail N. Zhadin a1
a1 Laboratory of Neurocybernetics, Institute of Cell Biophysics, 142292 Pushchino, Russia


The absence of a clear influence of the responses modified by new connections created by LTP on the development of these connections casts doubt on an essential role of LTP in learning and memory formation without any association with reinforcement. The evidence for the involvement of the monoaminergic systems in synaptic potentiation in the cerebral cortex during learning is adduced, and their role in reinforcement system function is discussed.