Behavioral and Brain Sciences

Open Peer Commentary

Negative affects are parts of the addiction syndrome

Michel Le Moala1

a1 Neurocentre Magendie, Institut François Magendie, Université Victor Segalen – Bordeaux 2, 33077 Bordeaux cedex, France.


Decision-making is a complex activity for which emotions and affects are essential. Maladaptive choices depend on negative affects. Vulnerabilities to drug or non-drug objects depend on previous psychopathological comorbidities. Premorbid individual characteristics allow us to understand why some individuals – and not others – enter into the addiction cycle. Moreover, plasticity of reward neurocircuitry is, at least in past, responsible for these vulnerabilities leading to compulsive drug use.