Behavioral and Brain Sciences

Open Peer Commentary
Fitch & Denenberg: Sexual differentiation of the brain

More evidence for the role of estrogens in female differentiation of the brain

Klaus D. Döhler a1
a1 Haemopep Pharma GmbH, D-30625 Hannover, Germany


Evidence accumulates that pre- and postnatally circulating estrogens play an active role in the differentiation of the female brain: the susceptible period for feminization of the brain seems to extend far beyond the period during which masculinization of the brain occurs. Thus, there is a need to reevaluate the widely accepted “concept of basic femaleness” in sexual brain differentiation.