Behavioral and Brain Sciences

Open Peer Commentary
Quartz & Sejnowski: Cognitive development

A causal relationship between LTP and learning? Has the question been answered by genetic approaches?

Robert Gerlai a1
a1 Neuroscience Department, Genentech, Inc. South San Francisco, CA 94080-4990


Gene targeting has generated a great deal of data on the molecular mechanisms of long-term potentiation and its potential role in learning and memory. However, the interpretation of some results has been questioned. Compensatory mechanisms and the contribution of genetic background may make it difficult to unequivocally prove the existence of a causal (genetic) link between LTP and learning.