Behavioral and Brain Sciences

Open Peer Commentary
Quartz & Sejnowski: Cognitive development

As in long-term memory, LTP is consolidated by reinforcers

Klaus G. Reymann a1
a1 Federal Institute for Neurobiology, Department of Neurophysiology, D-39008 Magdeburg, Germany


Recent evidence from our lab indicates that LTP shares an important property with memory consolidation: it is consolidated by natural reinforcement. Nevertheless, the hypothesis, that LTP-like mechanisms or other forms of enhanced synaptic efficacy are basic elements in learning is not unequivocally supported. Skepticism aside, LTP is an accessible experimental model that is optimally equipped for the investigation of the cellular and molecular machinery involved in synaptic weight changes.