Cambridge Journals Online

Review Article

Molecular pathogenesis and clinical implications of eczema herpeticum

Caroline Bussmanna1, Wen-Ming Penga1, Thomas Biebera1 and Natalija Novaka1 c1 a1 Department of Dermatology and Allergology, University of Bonn, Bonn, Germany.

Article author query bussmann c   peng w   bieber t   novak n

Abstract

A subgroup of patients with atopic dermatitis develops one or more episodes of a severe viral skin infection caused by herpes simplex virus superimposed on eczematous skin lesions. This condition is named atopic dermatitis complicated by eczema herpeticum. Characteristic features of patients developing eczema herpeticum include an early age of onset of atopic dermatitis with a persistent and severe course into adulthood, predilection for eczematous skin lesions in the head and neck area, elevated total serum IgE levels and increased allergen sensitisation. Deficiencies at the level of both the innate and the adaptive immune system, which have been identified in atopic dermatitis, are much more pronounced in this subgroup. Predisposing cellular factors include a reduced number of plasmacytoid dendritic cells in the epidermis and a modified capacity of these cells to produce type I interferons after allergen challenge. In addition, lower levels of antimicrobial peptides in the skin of atopic dermatitis patients, resulting in part from a Th2-prone micromilieu, contribute to the lack of an effective defence against viral attack. In this review, we summarise the current knowledge of the molecular pathogenesis of eczema herpeticum.

Correspondence:

^c1 Corresponding author: Natalija Novak, Department of Dermatology and Allergology, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany. Tel: +49 228 287 15370; Fax: +49 228 287 14333; E-mail: Natalija.Novak@ukb.uni-bonn.de